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Gene Ontology Classifications
achaete-scute complex homolog 1 (Drosophila)

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GO curators for mouse genes have assigned the following annotations to the gene product of Ascl1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Balmer CW et al. (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol, 472:292-307. (PubMed:15065125)
  2. Black BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem, 271:26659-63. (PubMed:8900141)
  3. Borges M et al. (1997) An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature, 386:852-5. (PubMed:9126746)
  4. Britz O et al. (2006) A role for proneural genes in the maturation of cortical progenitor cells. Cereb Cortex, 16 Suppl 1:i138-51. (PubMed:16766700)
  5. Casarosa S et al. (1999) Mash1 regulates neurogenesis in the ventral telencephalon. Development, 126:525-34. (PubMed:9876181)
  6. Castro DS et al. (2011) A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev, 25:930-45. (PubMed:21536733)
  7. Castro DS et al. (2006) Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell, 11:831-44. (PubMed:17141158)
  8. Cau E et al. (1997) Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development, 124:1611-1621. (PubMed:9108377)
  9. Chang JC et al. (2013) Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Dev Cell, 25:182-95. (PubMed:23639443)
  10. Choi PS et al. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron, 57:41-55. (PubMed:18184563)
  11. Farah MH et al. (2000) Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development, 127:693-702. (PubMed:10648228)
  12. Hartfuss E et al. (2001) Characterization of CNS precursor subtypes and radial glia. Dev Biol, 229:15-30. (PubMed:11133151)
  13. Huber K et al. (2002) Development of chromaffin cells depends on MASH1 function. Development, 129:4729-38. (PubMed:12361965)
  14. Hufnagel RB et al. (2010) Neurog2 controls the leading edge of neurogenesis in the mammalian retina. Dev Biol, 340:490-503. (PubMed:20144606)
  15. Ito T et al. (2000) Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium Development, 127:3913-21. (PubMed:10952889)
  16. Itoh Y et al. (2013) Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. Nat Neurosci, 16:416-25. (PubMed:23434913)
  17. Johnson JE et al. (1992) Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Development, 114:75-87. (PubMed:1576967)
  18. Kameda Y. (2005) Mash1 is required for glomus cell formation in the mouse carotid body. Dev Biol, 283:128-39. (PubMed:15878769)
  19. Kokubu H et al. (2008) Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells, 13:41-51. (PubMed:18173746)
  20. Kriks S et al. (2005) Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development, 132:2991-3002. (PubMed:15930101)
  21. Krolewski RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One, 7:e51737. (PubMed:23284756)
  22. Li RA et al. (2000) Molecular basis of electrocardiographic ST-segment elevation. Circ Res, 87:837-9. (PubMed:11073877)
  23. Li S et al. (2005) Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc Natl Acad Sci U S A, 102:10688-93. (PubMed:16020526)
  24. McNay DE et al. (2006) Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Mol Endocrinol, 20:1623-32. (PubMed:16469766)
  25. Miyoshi G et al. (2004) Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. J Neurosci, 24:3672-82. (PubMed:15071116)
  26. Mizuguchi R et al. (2006) Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci, 9:770-8. (PubMed:16715081)
  27. Morikawa Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development, 136:3575-84. (PubMed:19793887)
  28. Murray RC et al. (2003) Widespread defects in the primary olfactory pathway caused by loss of Mash1 function. J Neurosci, 23:1769-80. (PubMed:12629181)
  29. Nelson BR et al. (2009) Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn, 238:2163-2178. (PubMed:19191219)
  30. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  31. Ohsawa R et al. (2005) Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. J Neurosci, 25:5857-65. (PubMed:15976074)
  32. Pattyn A et al. (2004) Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci, 7:589-95. (PubMed:15133515)
  33. Petryniak MA et al. (2007) Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron, 55:417-33. (PubMed:17678855)
  34. Roza C et al. (2004) Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol, 558:659-69. (PubMed:15169849)
  35. Sommer L et al. (1995) The cellular function of MASH1 in autonomic neurogenesis. Neuron, 15:1245-58. (PubMed:8845150)
  36. Sugimori M et al. (2008) Ascl1 is required for oligodendrocyte development in the spinal cord. Development, 135:1271-81. (PubMed:18287202)
  37. Tiveron MC et al. (2003) Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus. Dev Biol, 260:46-57. (PubMed:12885554)
  38. Tomita K et al. (2000) Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system EMBO J, 19:5460-72. (PubMed:11032813)
  39. Virolainen SM et al. (2012) Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development, 139:3795-805. (PubMed:22991444)
  40. Wildner H et al. (2013) Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. J Neurosci, 33:7299-307. (PubMed:23616538)
  41. Wildner H et al. (2008) Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development, 135:473-81. (PubMed:18094025)
  42. Yun K et al. (2002) Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development, 129:5029-40. (PubMed:12397111)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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