Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lyz2. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lyz2
  • participates in the following biological processes:
    • defense response to Gram-negative bacterium ^[2]
    • defense response to Gram-positive bacterium ^[2]
    • metabolic process ^[1]
  • performs the following molecular functions:
    • lysozyme activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lyz2
  • participates in the following biological processes:
    • defense response to bacterium ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lyz2:
  • participates in the following biological processes:
    • defense response to Gram-negative bacterium
    • defense response to Gram-positive bacterium
  • performs the following molecular functions:
    • hydrolase activity, acting on glycosyl bonds
    • lysozyme activity
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum lumen
    • Golgi cis cisterna
    • Golgi stack
    • microvillus
    • rough endoplasmic reticulum lumen
    • secretory granule
    • trans-Golgi network transport vesicle

---

Summary text based on GO annotations supported by structural data

• Lyz2 encodes a protein or proteins that contain the following InterPro domains: Glycoside hydrolase, family 22, Glycoside hydrolase, family 22, conserved site, Glycoside hydrolase, family 22, lysozyme, Lysozyme-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • cell wall macromolecule catabolic process

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lyz2 indicates that it:
  • participates in the following biological processes:
    • cytolysis
  • performs the following molecular functions:
    • catalytic activity
    • hydrolase activity
  • is located in the following cellular components:
    • extracellular region

---

References

1. Ganz T et al. (2003) Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan. Blood, 101:2388-92. (PubMed:12411294)
2. Markart P et al. (2004) Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P. Biochem J, 380:385-92. (PubMed:14977423)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---