Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.2.0)

Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytoplasmic side of plasma membrane and cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1).

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Gene Ontology Evidence Code Abbreviations:

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