Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itgb4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Itgb4
  • is located in the following cellular components:
    • basal plasma membrane ^{[1, 4]}
    • basement membrane ^[5]
    • hemidesmosome ^[6]
    • integrin complex ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Itgb4
  • participates in the following biological processes:
    • cell adhesion ^[2]
    • filopodium assembly ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Itgb4:
  • participates in the following biological processes:
    • cell motility
    • hemidesmosome assembly
    • response to wounding
  • is located in the following cellular components:
    • cell cortex
    • cell leading edge
    • cell surface
    • cytoplasm
    • hemidesmosome
    • membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Itgb4 encodes a protein or proteins that contain the following InterPro domains: EGF-like, conserved site, Fibronectin, type III, Immunoglobulin-like fold, Integrin beta subunit, Integrin beta subunit, N-terminal, Integrin beta subunit, tail, Integrin beta-4 subunit, Na-Ca exchanger/integrin-beta4, Plexin-like fold, Plexin/semaphorin/integrin, von Willebrand factor, type A, indicating that the gene product:
  • participates in the following biological processes:
    • cell communication
    • cell-matrix adhesion
    • integrin-mediated signaling pathway
    • multicellular organismal development
  • performs the following molecular functions:
    • receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itgb4 indicates that it:
  • participates in the following biological processes:
    • integrin-mediated signaling pathway
  • is located in the following cellular components:
    • cell junction
    • integral to membrane

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References

1. Davies D et al. (2002) Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol, 445:122-32. (PubMed:11891657)
2. Dowling J et al. (1996) Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol, 134:559-72. (PubMed:8707838)
3. Fukumoto S et al. (2006) Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J Biol Chem, 281:5008-16. (PubMed:16365040)
4. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol, 193:235-50. (PubMed:21464233)
5. Raveh E et al. (2006) Dynamic expression of Runx1 in skin affects hair structure. Mech Dev, 123:842-50. (PubMed:17011173)
6. Romano RA et al. (2012) DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development, 139:772-82. (PubMed:22274697)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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