Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il5. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il5
  • participates in the following biological processes:
    • positive regulation of peptidyl-tyrosine phosphorylation ^[4]
    • positive regulation of sequence-specific DNA binding transcription factor activity ^[9]
    • positive regulation of transcription, DNA-dependent ^[9]
  • performs the following molecular functions:
    • cytokine activity ^[4]
  • is located in the following cellular components:
    • extracellular space ^{[1, 2, 3, 5, 6, 8]}
• Researchers have inferred, based on genetic interactions, that the gene product of Il5
  • participates in the following biological processes:
    • positive regulation of immunoglobulin secretion based on interactions with Il33 ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il5:
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway
    • positive regulation of B cell proliferation
    • positive regulation of cell proliferation
    • positive regulation of eosinophil differentiation
    • positive regulation of JAK-STAT cascade
    • positive regulation of podosome assembly
  • performs the following molecular functions:
    • cytokine activity
    • interleukin-5 receptor binding
  • is located in the following cellular components:
    • extracellular region

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Summary text based on GO annotations supported by structural data

• Il5 encodes a protein or proteins that contain the following InterPro domains: Four-helical cytokine, core, Four-helical cytokine-like, core, Interleukin-5, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • performs the following molecular functions:
    • growth factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il5 indicates that it:
  • performs the following molecular functions:
    • growth factor activity

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References

1. Chae WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A, 103:9631-6. (PubMed:16769892)
2. Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature, 407:916-20. (PubMed:11057672)
3. Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol, 9:1347-55. (PubMed:18997793)
4. Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun, 272:45-54. (PubMed:10872802)
5. Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol, 116:1106-15. (PubMed:16275384)
6. McKee AS et al. (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol, 173:1224-31. (PubMed:15240714)
7. Miller AM et al. (2008) IL-33 reduces the development of atherosclerosis. J Exp Med, 205:339-46. (PubMed:18268038)
8. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
9. Stuber E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity, 2:507-21. (PubMed:7749983)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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