Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of signal transduction. Localizes to the nucleus and transcription factor complex. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is expressed in several structures, including early conceptus; genitourinary system; neural ectoderm; paraxial mesenchyme; and retina. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).