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Gene Ontology Classifications
Symbol
Name
ID
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rbpj. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Amsen D et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity, 27:89-99. (PubMed:17658279)
  2. Apelqvist A et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature, 400:877-81. (PubMed:10476967)
  3. Blanpain C et al. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev, 20:3022-35. (PubMed:17079689)
  4. Chang JC et al. (2013) Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Dev Cell, 25:182-95. (PubMed:23639443)
  5. Dai Q et al. (2013) BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development, 140:1892-902. (PubMed:23571214)
  6. de la Pompa JL et al. (1997) Conservation of the Notch signalling pathway in mammalian neurogenesis. Development, 124:1139-48. (PubMed:9102301)
  7. Del Monte G et al. (2007) Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop. Dev Dyn, 236:2594-614. (PubMed:17685488)
  8. del Monte G et al. (2011) Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res, 108:824-36. (PubMed:21311046)
  9. Doetzlhofer A et al. (2009) Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell, 16:58-69. (PubMed:19154718)
  10. Fang TC et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity, 27:100-10. (PubMed:17658278)
  11. Ferjentsik Z et al. (2009) Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet, 5:e1000662. (PubMed:19779553)
  12. Grego-Bessa J et al. (2007) Notch signaling is essential for ventricular chamber development. Dev Cell, 12:415-29. (PubMed:17336907)
  13. Guha A et al. (2012) Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A, 109:12592-7. (PubMed:22797898)
  14. Jo HS et al. (2012) Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J, 31:817-28. (PubMed:22258620)
  15. Kim TH et al. (2011) Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med, 208:677-88. (PubMed:21402740)
  16. Klaus A et al. (2012) Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A, 109:10921-6. (PubMed:22711842)
  17. Krebs LT et al. (2003) Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev, 17:1207-12. (PubMed:12730124)
  18. Krebs LT et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev, 18:2469-73. (PubMed:15466160)
  19. Luna-Zurita L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest, 120:3493-507. (PubMed:20890042)
  20. Ma X et al. (2007) Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Mol Cell Biol, 27:3056-64. (PubMed:17283045)
  21. Masui T et al. (2007) Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev, 21:2629-43. (PubMed:17938243)
  22. Minoguchi S et al. (1997) RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol, 17:2679-87. (PubMed:9111338)
  23. Nus M et al. (2011) Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL. Arterioscler Thromb Vasc Biol, 31:1580-8. (PubMed:21493891)
  24. Obata J et al. (2001) p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells, 6:345-60. (PubMed:11318877)
  25. Oswald F et al. (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol, 25:10379-90. (PubMed:16287852)
  26. Robert-Moreno A et al. (2005) RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development, 132:1117-26. (PubMed:15689374)
  27. Satpathy AT et al. (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol, 14:937-48. (PubMed:23913046)
  28. Tamura K et al. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol, 5:1416-23. (PubMed:8749394)
  29. Tanigaki K et al. (2002) Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol, 3:443-50. (PubMed:11967543)
  30. Timmerman LA et al. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev, 18:99-115. (PubMed:14701881)
  31. Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol, 184:101-12. (PubMed:19124651)
  32. Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature, 446:882-7. (PubMed:17392792)
  33. Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci, 24:9497-506. (PubMed:15509736)
  34. Yun TJ et al. (2003) Notch-regulated ankyrin-repeat protein inhibits notch1 signaling: multiple notch1 signaling pathways involved in T cell development. J Immunol, 170:5834-41. (PubMed:12794108)
  35. Zhu X et al. (2006) Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev, 20:2739-53. (PubMed:17015435)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory