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Gene Ontology Classifications
insulin-like growth factor 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Igf1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Begue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol, 38:405-20. (PubMed:7848824)
  2. Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell, 3:631-43. (PubMed:12431371)
  3. Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol, 139:431-9. (PubMed:7510770)
  4. Donahue LR et al. (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol, 136:91-104. (PubMed:7679139)
  5. Font de Mora J et al. (2003) Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J, 22:3039-49. (PubMed:12805218)
  6. Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet, 18:4629-39. (PubMed:19744960)
  7. Kido Y et al. (2002) Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J Biol Chem, 277:36740-7. (PubMed:12101187)
  8. Kim JS et al. (2007) Cytokine-like 1 (CYTL1) Regulates the Chondrogenesis of Mesenchymal Cells. J Biol Chem, 282:29359-67. (PubMed:17644814)
  9. Kleinberg DL et al. (2007) Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice. Endocrinology, 148:1080-8. (PubMed:17138659)
  10. Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130:456-69. (PubMed:17693256)
  11. Li Y et al. (2003) PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology, 144:3505-13. (PubMed:12865332)
  12. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
  13. Matheny RW Jr et al. (2011) Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation. Endocrinology, 152:1923-34. (PubMed:21406500)
  14. McCusker RH et al. (2003) Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol, 197:388-99. (PubMed:14566968)
  15. Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos Dev Dyn, 235:2040-50. (PubMed:16691571)
  16. Mukherjee A et al. (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci, 122:716-26. (PubMed:19208758)
  17. Pearce LR et al. (2011) Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J, 436:169-79. (PubMed:21413931)
  18. Podcheko A et al. (2007) Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol, 27:6484-96. (PubMed:17636024)
  19. Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology, 145:3106-10. (PubMed:15059953)
  20. Ruan W et al. (1999) Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology, 140:1984-9. (PubMed:10218945)
  21. Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci, 23:7084-92. (PubMed:12904469)
  22. Stefaneanu L et al. (1999) Somatotroph and lactotroph changes in the adenohypophyses of mice with disrupted insulin-like growth factor I gene. Endocrinology, 140:3881-9. (PubMed:10465256)
  23. Sun X et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun, 377:1097-101. (PubMed:18977203)
  24. Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol, 199:489-97. (PubMed:18827067)
  25. Teglund S et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell, 93:841-50. (PubMed:9630227)
  26. Vicario-Abejon C et al. (2003) Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci, 23:895-906. (PubMed:12574418)
  27. Vinals F et al. (2004) Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. J Biol Chem, 279:45766-72. (PubMed:15322112)
  28. Wechsler-Reya RJ et al. (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog [see comments] Neuron, 22:103-14. (PubMed:10027293)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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