GO Annotations Graph

• Symbol: Igf1
• Name: insulin-like growth factor 1
• ID: MGI:96432

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	IDA	J:186813
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IPI	J:86296
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:86296
Molecular Function	GO:0005515	protein binding	IPI	J:3735
Molecular Function	GO:0005515	protein binding	IPI	J:3735
Molecular Function	GO:0005515	protein binding	IPI	J:3735
Molecular Function	GO:0005515	protein binding	IPI	J:3735
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:294899
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:327222
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:290858
Molecular Function	GO:0005496	steroid binding	ISO	J:155856
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IGI	J:294899
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:327222
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ISO	J:290858
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0070382	exocytic vesicle	IDA	J:229369
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:77412
Cellular Component	GO:0005615	extracellular space	IDA	J:126780
Cellular Component	GO:0005615	extracellular space	IDA	J:16863
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:253231
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:253231
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:253231
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:253231
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	TAS	J:89234
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	ISO	J:164563
Cellular Component	GO:0005614	interstitial matrix	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0099013	neuronal dense core vesicle lumen	IMP	J:253231
Cellular Component	GO:0099013	neuronal dense core vesicle lumen	IDA	J:253231
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:155856
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0030521	androgen receptor signaling pathway	IMP	J:142809
Biological Process	GO:0030521	androgen receptor signaling pathway	IMP	J:142809
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:110719
Biological Process	GO:0001974	blood vessel remodeling	IGI	J:110719
Biological Process	GO:0035630	bone mineralization involved in bone maturation	ISO	J:164563
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:105630
Biological Process	GO:0001775	cell activation	ISO	J:199676
Biological Process	GO:0048468	cell development	IMP	J:108805
Biological Process	GO:0048468	cell development	IMP	J:108805
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:110719
Biological Process	GO:0008283	cell population proliferation	IGI	J:125126
Biological Process	GO:0008283	cell population proliferation	IGI	J:125126
Biological Process	GO:0008283	cell population proliferation	IGI	J:110719
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0071333	cellular response to glucose stimulus	IDA	J:186813
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	IMP	J:186813
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	IDA	J:125386
Biological Process	GO:0007623	circadian rhythm	IEP	J:165676
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:79280
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:88139
Biological Process	GO:0010001	glial cell differentiation	IMP	J:81918
Biological Process	GO:0048839	inner ear development	IDA	J:174607
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:15108
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:294899
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:290858
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:83950
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0048286	lung alveolus development	IMP	J:110719
Biological Process	GO:0048286	lung alveolus development	IGI	J:110719
Biological Process	GO:0048286	lung alveolus development	IMP	J:110719
Biological Process	GO:0048286	lung alveolus development	IMP	J:110719
Biological Process	GO:0030324	lung development	IGI	J:110719
Biological Process	GO:0060463	lung lobe morphogenesis	IMP	J:110719
Biological Process	GO:0060463	lung lobe morphogenesis	IGI	J:110719
Biological Process	GO:0060426	lung vasculature development	IMP	J:110719
Biological Process	GO:0060426	lung vasculature development	IGI	J:110719
Biological Process	GO:0060426	lung vasculature development	IGI	J:110719
Biological Process	GO:0060426	lung vasculature development	IMP	J:110719
Biological Process	GO:0030879	mammary gland development	IMP	J:105630
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0035264	multicellular organism growth	IDA	J:84818
Biological Process	GO:0014896	muscle hypertrophy	ISO	J:164563
Biological Process	GO:0045445	myoblast differentiation	ISO	J:164563
Biological Process	GO:0051450	myoblast proliferation	ISO	J:164563
Biological Process	GO:0014904	myotube cell development	ISO	J:164563
Biological Process	GO:0014902	myotube differentiation	IDA	J:213615
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	IMP	J:142809
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:177251
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:84857
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:110719
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:110719
Biological Process	GO:1904193	negative regulation of cholangiocyte apoptotic process	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:110719
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:168129
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0002683	negative regulation of immune system process	ISO	J:155856
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:1900142	negative regulation of oligodendrocyte apoptotic process	ISO	J:155856
Biological Process	GO:0060283	negative regulation of oocyte development	ISO	J:164563
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IMP	J:186813
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	IDA	J:177251
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:81918
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:143682
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IDA	J:172256
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:155856
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	ISO	J:164563
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0031643	positive regulation of myelination	IDA	J:252137
Biological Process	GO:2000288	positive regulation of myoblast proliferation	IMP	J:173969
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:172256
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:146446
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:110719
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:125386
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110719
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:94493
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:1904075	positive regulation of trophectodermal cell proliferation	ISO	J:164563
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:253231
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:253231
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP	J:54846
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:129595
Biological Process	GO:0060736	prostate gland growth	IMP	J:142809
Biological Process	GO:0060736	prostate gland growth	IDA	J:129595
Biological Process	GO:0060736	prostate gland growth	IMP	J:142809
Biological Process	GO:0060741	prostate gland stromal morphogenesis	IMP	J:129595
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0030166	proteoglycan biosynthetic process	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	IDA	J:21055
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	ISO	J:73065
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	IMP	J:186813
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	IMP	J:186813
Biological Process	GO:0051246	regulation of protein metabolic process	IGI	J:16863
Biological Process	GO:0001932	regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:153971
Biological Process	GO:0006417	regulation of translation	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:164563
Biological Process	GO:0007608	sensory perception of smell	TAS	J:229369
Biological Process	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	ISO	J:164563
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:0060509	type I pneumocyte differentiation	IMP	J:110719
Biological Process	GO:0060510	type II pneumocyte differentiation	IMP	J:110719
Biological Process	GO:0042060	wound healing	ISO	J:164563