GO curators for mouse genes have assigned the following annotations to the gene product of Htr1b. (This text reflects annotations as of Thursday, July 24, 2014.) Summary from NCBI RefSeq
[Summary is not available for the mouse gene. This summary is for the human ortholog.] The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]Summary text based on GO annotations supported by experimental evidence in mouse
Researchers have inferred from direct assay, that the gene product of Htr1b
participates in the following biological processes:
Janoshazi A et al. (2007) Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol Pharmacol, 71:1463-74. (PubMed:17325130)
Saudou F et al. (1993) The Mouse 5-HT(1B)-Serotonin Receptor - Cloning, Functional Expression, and Localization in Motor Control Centers null, null:201-209.
Trillat AC et al. (1997) Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. J Neurochem, 69:2019-25. (PubMed:9349547)