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Gene Ontology Classifications
homeobox A2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hoxa2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Davenne M et al. (1999) Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron, 22:677-91. (PubMed:10230789)
  2. Dobreva G et al. (2006) SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell, 125:971-86. (PubMed:16751105)
  3. Fung KM et al. (1994) Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. Lab Invest, 70:114-24. (PubMed:7508007)
  4. Gavalas A et al. (1997) Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development, 124:3693-702. (PubMed:9367425)
  5. Gendron-Maguire M et al. (1993) Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell, 75:1317-31. (PubMed:7903600)
  6. Hao Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev Dyn, 216:201-17. (PubMed:10536059)
  7. Hu R et al. (2011) A Runx2/miR-3960/miR-2861 Regulatory Feedback Loop during Mouse Osteoblast Differentiation. J Biol Chem, 286:12328-39. (PubMed:21324897)
  8. Kutejova E et al. (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development, 132:469-78. (PubMed:15634706)
  9. Maamar H et al. (2013) linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev, 27:1260-71. (PubMed:23723417)
  10. O'Gorman S. (2005) Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice. Dev Dyn, 234:124-31. (PubMed:15861402)
  11. Rijli FM et al. (1993) A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene. Cell, 75:1333-49. (PubMed:7903601)
  12. Santagati F et al. (2005) Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development, 132:4927-36. (PubMed:16221728)
  13. Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development, 135:3369-78. (PubMed:18787068)
  14. Wolf LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport, 12:329-33. (PubMed:11209945)
  15. Yang X et al. (2008) Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol, 314:171-88. (PubMed:18164701)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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