Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hmga1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hmga1
  • performs the following molecular functions:
    • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ^[2]
  • is located in the following cellular components:
    • nucleus ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hmga1
  • participates in the following biological processes:
    • spermatogenesis ^[3]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hmga1:
  • participates in the following biological processes:
    • base-excision repair
    • negative regulation of cell proliferation
    • negative regulation of transcription, DNA-dependent
    • oncogene-induced senescence
    • positive regulation of cellular senescence
    • positive regulation of transcription, DNA-dependent
    • senescence-associated heterochromatin focus assembly
  • performs the following molecular functions:
    • 5'-deoxyribose-5-phosphate lyase activity
    • DNA-(apurinic or apyrimidinic site) lyase activity
    • enzyme binding
    • ligand-dependent nuclear receptor transcription coactivator activity
    • peroxisome proliferator activated receptor binding
    • retinoic acid receptor binding
    • retinoid X receptor binding
    • sequence-specific DNA binding transcription factor activity
    • transcription factor binding
  • is located in the following cellular components:
    • nucleus
    • senescence-associated heterochromatin focus

---

References

1. Chieffi P et al. (2002) HMGA1 and HMGA2 protein expression in mouse spermatogenesis. Oncogene, 21:3644-50. (PubMed:12032866)
2. De Martino I et al. (2009) HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res, 69:1844-50. (PubMed:19223528)
3. Liu J et al. (2003) Hmga1 is required for normal sperm development. Mol Reprod Dev, 66:81-9. (PubMed:12874803)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---