Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of H2-D1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of H2-D1
  • participates in the following biological processes:
    • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent ^[1]
    • positive regulation of T cell mediated cytotoxicity ^[1]
  • is located in the following cellular components:
    • external side of plasma membrane ^{[1, 3]}
    • plasma membrane ^[2]
• The gene product of H2-D1 has been shown to bind to the gene products of B2m, Tap1, Tap2. ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of H2-D1:
  • participates in the following biological processes:
    • detection of bacterium
    • immune response
    • regulation of dendritic cell differentiation
    • regulation of interleukin-12 production
    • regulation of interleukin-6 production
    • regulation of T cell anergy
  • performs the following molecular functions:
    • receptor binding

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Summary text based on GO annotations supported by structural data

• H2-D1 encodes a protein or proteins that contain the following InterPro domains: Cytochrome c1, transmembrane anchor, C-terminal, Immunoglobulin C1-set, Immunoglobulin-like, Immunoglobulin-like fold, Immunoglobulin/major histocompatibility complex, conserved site, MHC class I, alpha chain, alpha1/alpha2, MHC class I, alpha chain, C-terminal, MHC class I-like antigen recognition, MHC classes I/II-like antigen recognition protein, indicating that the gene product:
  • participates in the following biological processes:
    • antigen processing and presentation
  • is located in the following cellular components:
    • membrane
    • MHC class I protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe H2-D1 indicates that it:
  • participates in the following biological processes:
    • antigen processing and presentation of peptide antigen via MHC class I
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • MHC class I protein complex

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References

1. Attaya M et al. (1992) Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature, 355:647-9. (PubMed:1538753)
2. Lilic M et al. (2004) Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics, 55:740-7. (PubMed:14735325)
3. Tajima A et al. (2003) Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo. J Immunol, 171:1715-21. (PubMed:12902470)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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