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Gene Ontology Classifications
nuclear receptor subfamily 3, group C, member 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nr3c1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Almeida OF et al. (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J, 14:779-90. (PubMed:10744634)
  2. Cole TJ et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev, 9:1608-21. (PubMed:7628695)
  3. Cole TJ et al. (1999) The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene. Mol Cell Endocrinol, 154:29-36. (PubMed:10509797)
  4. Davies TH et al. (2002) A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem, 277:4597-600. (PubMed:11751894)
  5. Gonzalez MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol Cell Endocrinol, 190:39-49. (PubMed:11997177)
  6. Goriki A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol, 12:e1001839. (PubMed:24736997)
  7. Hinds TD Jr et al. (2010) Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol, 24:1715-27. (PubMed:20660300)
  8. Jaskoll T et al. (1994) Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J Craniofac Genet Dev Biol, 14:217-30. (PubMed:7883868)
  9. Ki SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol Cell Biol, 25:4150-65. (PubMed:15870285)
  10. Kingsley-Kallesen M et al. (2002) The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Mol Endocrinol, 16:2008-18. (PubMed:12198239)
  11. Lamia KA et al. (2011) Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature, 480:552-6. (PubMed:22170608)
  12. Martyn AC et al. (2012) Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Mol Cell Biol, 32:5140-50. (PubMed:23071095)
  13. Pazirandeh A et al. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J, 13:893-901. (PubMed:10224232)
  14. Sitz JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol, 24:5821-34. (PubMed:15199138)
  15. Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet, 10:1995-2011. (PubMed:11555636)
  16. Tomomura M et al. (1994) Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Biochim Biophys Acta, 1226:307-14. (PubMed:7914432)
  17. Van Houten N et al. (1997) Elevated expression of Bcl-2 and Bcl-x by intestinal intraepithelial lymphocytes: resistance to apoptosis by glucocorticoids and irradiation. Int Immunol, 9:945-53. (PubMed:9237103)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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