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Gene Ontology Classifications
glutamate receptor, ionotropic, kainate 2 (beta 2)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grik2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 15, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Adelbrecht C et al. (1997) An immunocytochemical study of a G-protein-gated inward rectifier K+ channel (GIRK2) in the weaver mouse mesencephalon. Neuroreport, 8:969-74. (PubMed:9141074)
  2. Bureau I et al. (1999) Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J Neurosci, 19:653-63. (PubMed:9880586)
  3. Casassus G et al. (2002) Functional characterization of kainate receptors in the mouse nucleus accumbens. Neuropharmacology, 42:603-11. (PubMed:11985817)
  4. Chergui K et al. (2000) Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. J Neurosci, 20:2175-82. (PubMed:10704492)
  5. Christensen JK et al. (2004) A mosaic of functional kainate receptors in hippocampal interneurons. J Neurosci, 24:8986-93. (PubMed:15483117)
  6. Contractor A et al. (2000) Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J Neurosci, 20:8269-78. (PubMed:11069933)
  7. Contractor A et al. (2001) Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron, 29:209-16. (PubMed:11182092)
  8. Coussen F et al. (2002) Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. J Neurosci, 22:6426-36. (PubMed:12151522)
  9. Darstein M et al. (2003) Distribution of kainate receptor subunits at hippocampal mossy fiber synapses. J Neurosci, 23:8013-9. (PubMed:12954862)
  10. Fisahn A. (2005) Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool. J Physiol, 562:65-72. (PubMed:15513934)
  11. Fisahn A et al. (2005) The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones. J Physiol, 562:199-203. (PubMed:15539395)
  12. Fisahn A et al. (2004) Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations. J Neurosci, 24:9658-68. (PubMed:15509753)
  13. Honda H et al. (1998) Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias. Blood, 91:2067-75. (PubMed:9490692)
  14. Jaskolski F et al. (2004) Subunit composition and alternative splicing regulate membrane delivery of kainate receptors. J Neurosci, 24:2506-15. (PubMed:15014126)
  15. Jensen P et al. (1999) Rescue of cerebellar granule cells from death in weaver NR1 double mutants. J Neurosci, 19:7991-8. (PubMed:10479699)
  16. Kayadjanian N et al. (2007) Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Mol Cell Neurosci, 34:219-30. (PubMed:17174564)
  17. Kerchner GA et al. (2002) Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. J Neurosci, 22:8010-7. (PubMed:12223554)
  18. Ko S et al. (2005) Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice. J Neurosci, 25:977-84. (PubMed:15673679)
  19. Mulle C et al. (2000) Subunit composition of kainate receptors in hippocampal interneurons Neuron, 28:475-84. (PubMed:11144357)
  20. Mulle C et al. (1998) Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature, 392:601-5. (PubMed:9580260)
  21. Rebola N et al. (2007) Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses. J Neurosci, 27:3987-93. (PubMed:17428973)
  22. Ruiz A et al. (2005) Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. J Neurosci, 25:11710-8. (PubMed:16354929)
  23. Sakimura K et al. (1992) Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron, 8:267-74. (PubMed:1310861)
  24. Schmitz D et al. (2003) Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci, 6:1058-63. (PubMed:12947409)
  25. Tang M et al. (2011) Neto1 Is an Auxiliary Subunit of Native Synaptic Kainate Receptors. J Neurosci, 31:10009-10018. (PubMed:21734292)
  26. Wu LJ et al. (2005) Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. J Neurophysiol, 94:1805-13. (PubMed:15928066)
  27. Youn DH et al. (2005) Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice. Brain Res Mol Brain Res, 142:9-18. (PubMed:16219388)
  28. Youn DH et al. (2004) Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit. J Physiol, 555:683-98. (PubMed:14724198)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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