Automated description from the Alliance of Genome Resources
Exhibits kainate selective glutamate receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including behavioral fear response; chemical synaptic transmission; and modulation of chemical synaptic transmission. Localizes to several cellular components, including the hippocampal mossy fiber to CA3 synapse; kainate selective glutamate receptor complex; and synaptic membrane. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Is expressed in several structures, including arterial system; gut; metanephros; nervous system; and testis. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2).