Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables kainate selective glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of cold stimulus involved in thermoception. Acts upstream of or within several processes, including behavioral fear response; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in neuronal cell body; postsynaptic density; and synaptic membrane. Part of kainate selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and mossy fiber rosette. Is expressed in several structures, including arterial system; central nervous system; eye; gut; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive intellectual developmental disorder 6. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2).
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