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Gene Ontology Classifications
growth hormone releasing hormone receptor

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ghrhr. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 25, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Beamer WH et al. (1976) Stimulation of growth in the little mouse. J Endocrinol, 71:37-45. (PubMed:978118)
  2. Bunger L et al. (1999) Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness. Genet Res, 74:351-60. (PubMed:10689811)
  3. Cheng TC et al. (1983) Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology, 113:1669-78. (PubMed:6194978)
  4. Christensen E et al. (1981) Fine structure of somatotrophs and mammotrophs in the pituitary pars distalis of the little (lit) mutant mouse. Virchows Arch B Cell Pathol Incl Mol Pathol, 37:89-96. (PubMed:6116352)
  5. Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol, 139:431-9. (PubMed:7510770)
  6. Donahue LR et al. (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol, 136:91-104. (PubMed:7679139)
  7. Eicher EM et al. (1976) Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered, 67:87-91. (PubMed:1270792)
  8. Flurkey K et al. (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A, 98:6736-41. (PubMed:11371619)
  9. Gaylinn BD et al. (1999) The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH. Endocrinology, 140:5066-74. (PubMed:10537133)
  10. Godfrey P et al. (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet, 4:227-32. (PubMed:8395283)
  11. Greenhalgh CJ et al. (2005) SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest, 115:397-406. (PubMed:15690087)
  12. Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology, 112:2032-8. (PubMed:6303755)
  13. Jansson JO et al. (1986) Receptor-associated resistance to growth hormone-releasing factor in dwarf little mice. Science, 232:511-2. (PubMed:3008329)
  14. Kiaris H et al. (2002) Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A, 99:196-200. (PubMed:11773624)
  15. Lin C et al. (1992) Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth [see comments] Nature, 360:765-8. (PubMed:1334535)
  16. Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth [see comments] Nature, 364:208-13. (PubMed:8391647)
  17. Luque RM et al. (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology, 147:2754-63. (PubMed:16513828)
  18. Niermann GL et al. (1999) Growth hormone and insulin-like growth factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney. Mol Cell Endocrinol, 153:47-55. (PubMed:10459853)
  19. Nissley SP et al. (1980) Somatomedin activity in sera of genetically small mice. Horm Metab Res, 12:158-64. (PubMed:7390396)
  20. Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology, 145:3106-10. (PubMed:15059953)
  21. Wilson DB et al. (1992) Histopathology of the pituitary gland in neonatal little (lit) mutant mice. Histol Histopathol, 7:451-5. (PubMed:1504465)
  22. Wilson DB et al. (1986) Growth hormone and prolactin immunoreactivity in the pituitary gland of postnatal little (lit) mice. Histol Histopathol, 1:309-13. (PubMed:2980124)
  23. Wilson DB et al. (1992) Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse. Anat Embryol (Berl), 186:347-53. (PubMed:1329576)
  24. Woodall SM et al. (1991) The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice. Horm Metab Res, 23:581-4. (PubMed:1778592)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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