Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fn1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fn1
  • participates in the following biological processes:
    • calcium-independent cell-matrix adhesion ^[3]
    • cell adhesion ^{[13, 16]}
    • cell-matrix adhesion ^[12]
    • cell-substrate junction assembly ^[5]
    • positive regulation of peptidase activity ^[6]
  • performs the following molecular functions:
    • peptidase activator activity ^[6]
  • is located in the following cellular components:
    • apical plasma membrane ^[7]
    • basement membrane ^{[8, 10]}
    • extracellular matrix ^{[1, 4, 8, 14]}
    • proteinaceous extracellular matrix ^{[2, 12]}
• The gene product of Fn1 has been shown to bind to the gene products of Mfap2, Plcg2. ^{[11, 15]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fn1
  • participates in the following biological processes:
    • wound healing ^[9]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fn1:
  • participates in the following biological processes:
    • cell activation
    • cell-matrix adhesion
    • cellular response to interleukin-1
    • cellular response to mercury ion
    • extracellular matrix organization
    • glial cell migration
    • negative regulation of apoptotic process
    • peptide cross-linking
    • positive regulation of cell migration
    • positive regulation of chemotaxis
    • substrate adhesion-dependent cell spreading
  • performs the following molecular functions:
    • mercury ion binding
    • protease binding
  • is located in the following cellular components:
    • basement membrane
    • endoplasmic reticulum-Golgi intermediate compartment
    • extracellular matrix
    • extracellular space
    • fibrinogen complex

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Summary text based on GO annotations supported by structural data

• Fn1 encodes a protein or proteins that contain the following InterPro domains: Complement control module, Fibronectin, type I, Fibronectin, type II, collagen-binding, Fibronectin, type III, Immunoglobulin-like fold, Kringle-like fold, indicating that the gene product:
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fn1 indicates that it:
  • participates in the following biological processes:
    • acute-phase response
    • angiogenesis
    • regulation of cell shape
  • performs the following molecular functions:
    • heparin binding
  • is located in the following cellular components:
    • extracellular region

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References

1. Balmer CW et al. (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol, 472:292-307. (PubMed:15065125)
2. Brown HC et al. (1997) Adhesion molecules involved in macrophage responses to Wallerian degeneration in the murine peripheral nervous system. Eur J Neurosci, 9:2057-63. (PubMed:9421166)
3. Gebauer JM et al. (2009) Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol, 28:456-62. (PubMed:19651211)
4. Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development, 109:29-36. (PubMed:2209468)
5. Jiang G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature, 424:334-7. (PubMed:12867986)
6. Lee NV et al. (2005) Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem, 280:34796-804. (PubMed:16061471)
7. Littlewood Evans A et al. (2000) Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet, 24:424-8. (PubMed:10742111)
8. Lozanoff S et al. (2001) Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem, 49:1081-97. (PubMed:11511678)
9. Muro AF et al. (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol, 162:149-60. (PubMed:12847088)
10. Ohsaki Y et al. (1995) Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel), 153:161-7. (PubMed:8984825)
11. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
12. Pratt SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol, 168:813-24. (PubMed:15728191)
13. Sengbusch JK et al. (2002) Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol, 157:873-82. (PubMed:12021259)
14. Trindade A et al. (2008) Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood, 112:1720-9. (PubMed:18559979)
15. Werneck CC et al. (2008) Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood, 111:4137-44. (PubMed:18281502)
16. Wong M et al. (1997) Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol, 192:492-508. (PubMed:9441684)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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