GO Annotations Graph

• Symbol: Fn1
• Name: fibronectin 1
• ID: MGI:95566

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0008201	heparin binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0045340	mercury ion binding	ISO	J:155856
Molecular Function	GO:0016504	peptidase activator activity	IDA	J:102464
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:134343
Molecular Function	GO:0043394	proteoglycan binding	IBA	J:265628
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:255711
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IDA	J:314650
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:61486
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	IDA	J:30059
Cellular Component	GO:0005604	basement membrane	IDA	J:202984
Cellular Component	GO:0005604	basement membrane	IDA	J:30059
Cellular Component	GO:0005604	basement membrane	IDA	J:71108
Cellular Component	GO:0005604	basement membrane	IDA	J:30059
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:311083
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	ISO	J:229828
Cellular Component	GO:0031012	extracellular matrix	IDA	J:138721
Cellular Component	GO:0031012	extracellular matrix	TAS	J:78447
Cellular Component	GO:0031012	extracellular matrix	IDA	J:32939
Cellular Component	GO:0031012	extracellular matrix	IDA	J:98248
Cellular Component	GO:0031012	extracellular matrix	IDA	J:44796
Cellular Component	GO:0031012	extracellular matrix	IDA	J:188490
Cellular Component	GO:0031012	extracellular matrix	IDA	J:71108
Cellular Component	GO:0031012	extracellular matrix	IDA	J:109287
Cellular Component	GO:0031012	extracellular matrix	IDA	J:191757
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005577	fibrinogen complex	ISO	J:164563
Biological Process	GO:0006953	acute-phase response	IEA	J:60000
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0051702	biological process involved in interaction with symbiont	ISO	J:164563
Biological Process	GO:0007161	calcium-independent cell-matrix adhesion	IDA	J:154510
Biological Process	GO:0001775	cell activation	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IDA	J:45322
Biological Process	GO:0007155	cell adhesion	IDA	J:76747
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:155856
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	IDA	J:98248
Biological Process	GO:0007044	cell-substrate junction assembly	IBA	J:265628
Biological Process	GO:0007044	cell-substrate junction assembly	IDA	J:84472
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0071288	cellular response to mercury ion	ISO	J:155856
Biological Process	GO:0035987	endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0030198	extracellular matrix organization	ISO	J:155856
Biological Process	GO:0008347	glial cell migration	ISO	J:155856
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0033622	integrin activation	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0150102	negative regulation of monocyte activation	ISO	J:164563
Biological Process	GO:0150102	negative regulation of monocyte activation	IDA	J:314650
Biological Process	GO:0071635	negative regulation of transforming growth factor beta production	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	ISO	J:229828
Biological Process	GO:0018149	peptide cross-linking	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	IDA	J:87191
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IEA	J:60000
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0042060	wound healing	IMP	J:84274