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Gene Ontology Classifications
fibroblast growth factor receptor 3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fgfr3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Arnaud-Dabernat S et al. (2007) FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Diabetes, 56:96-106. (PubMed:17192470)
  2. Cho JY et al. (2004) Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A, 101:609-14. (PubMed:14699054)
  3. Davidson D et al. (2005) Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem, 280:20509-15. (PubMed:15781473)
  4. Govindarajan V et al. (2001) Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development, 128:1617-27. (PubMed:11290300)
  5. Hayashi T et al. (2007) Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn, 236:525-33. (PubMed:17117437)
  6. Inglis-Broadgate SL et al. (2005) FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Dev Biol, 279:73-85. (PubMed:15708559)
  7. Jungnickel J et al. (2005) Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience, 134:1343-50. (PubMed:16009496)
  8. Kong M et al. (2002) Interaction of Fibroblast Growth Factor Receptor 3 and the Adapter Protein SH2-B. A ROLE IN STAT5 ACTIVATION. J Biol Chem, 277:15962-70. (PubMed:11827956)
  9. Kurosu H et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem, 281:6120-3. (PubMed:16436388)
  10. Mueller KL et al. (2002) Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci, 22:9368-77. (PubMed:12417662)
  11. Murashima-Suginami A et al. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun, 359:549-55. (PubMed:17555714)
  12. Naski MC et al. (1998) Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development, 125:4977-88. (PubMed:9811582)
  13. Oh LY et al. (2003) Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. J Neurosci, 23:883-94. (PubMed:12574417)
  14. Puligilla C et al. (2007) Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn, 236:1905-17. (PubMed:17557302)
  15. Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell, 17:576-84. (PubMed:16291864)
  16. Su N et al. (2010) Generation of Fgfr3 conditional knockout mice. Int J Biol Sci, 6:327-32. (PubMed:20582225)
  17. Suzuki M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol, 22:1006-14. (PubMed:18187602)
  18. Timmer M et al. (2007) Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J Neurosci, 27:459-71. (PubMed:17234579)
  19. Vidrich A et al. (2009) Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development. Am J Physiol Gastrointest Liver Physiol, 297:G168-78. (PubMed:19407216)
  20. Weinstein M et al. (1998) FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development, 125:3615-23. (PubMed:9716527)
  21. Zhao H et al. (2008) Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol, 318:276-88. (PubMed:18455718)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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