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Gene Ontology Classifications
Fc receptor, IgE, high affinity I, gamma polypeptide

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GO curators for mouse genes have assigned the following annotations to the gene product of Fcer1g. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Azeredo da Silveira S et al. (2002) Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med, 195:665-72. (PubMed:11901193)
  2. Barnes N et al. (2002) FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Immunity, 16:379-89. (PubMed:11911823)
  3. Bezbradica JS et al. (2014) A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol, 15:333-42. (PubMed:24608040)
  4. Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene, 13:2595-605. (PubMed:9000133)
  5. Coxon A et al. (2001) Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity, 14:693-704. (PubMed:11420040)
  6. Craig AW et al. (2002) Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol, 22:6363-74. (PubMed:12192036)
  7. Heller T et al. (1999) Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis. J Immunol, 162:5657-61. (PubMed:10229794)
  8. Hellwig SM et al. (2001) Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis. J Infect Dis, 183:871-9. (PubMed:11237803)
  9. Ioan-Facsinay A et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity, 16:391-402. (PubMed:11911824)
  10. Kumagai H et al. (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun, 307:719-29. (PubMed:12893283)
  11. Miyake Y et al. (2013) C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity, 38:1050-62. (PubMed:23602766)
  12. Mocsai A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol, 7:1326-33. (PubMed:17086186)
  13. Nakano T et al. (2008) Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV. Mol Immunol, 45:289-294. (PubMed:17543387)
  14. Poole A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J, 16:2333-41. (PubMed:9171347)
  15. Ra C et al. (1989) Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J Biol Chem, 264:15323-7. (PubMed:2527850)
  16. Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol, 172:2374-81. (PubMed:14764707)
  17. Sato K et al. (2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem, 281:38854-66. (PubMed:17050534)
  18. Sylvestre D et al. (1996) Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med, 184:2385-92. (PubMed:8976192)
  19. Wernersson S et al. (1999) IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol, 163:618-22. (PubMed:10395649)
  20. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:21-32. (PubMed:14643301)
  21. Yamasaki S et al. (2008) Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol, 9:1179-88. (PubMed:18776906)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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