Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fcer1g. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fcer1g
  • participates in the following biological processes:
    • cell surface receptor signaling pathway ^[3]
    • Fc-epsilon receptor signaling pathway ^[13]
    • mast cell activation ^[13]
    • negative regulation of mast cell apoptotic process ^[13]
    • positive regulation of interleukin-6 production ^[13]
    • positive regulation of mast cell cytokine production ^[13]
    • positive regulation of mast cell degranulation ^[13]
    • positive regulation of tumor necrosis factor production ^[13]
    • signal transduction ^[5]
  • performs the following molecular functions:
    • IgE binding ^{[12, 13]}
    • IgE receptor activity ^[13]
  • is located in the following cellular components:
    • external side of plasma membrane ^{[12, 13]}
    • integral to plasma membrane ^[12]
• The gene product of Fcer1g has been shown to bind to the gene products of Clec4e, Clec4n, Syk. ^{[9, 10, 14, 18]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fcer1g
  • participates in the following biological processes:
    • antigen processing and presentation of exogenous peptide antigen via MHC class I ^[8]
    • antigen processing and presentation of exogenous peptide antigen via MHC class II ^[17]
    • cell surface receptor signaling pathway ^{[2, 8]}
    • defense response to bacterium ^[7]
    • Fc receptor mediated stimulatory signaling pathway ^[13]
    • Fc-epsilon receptor signaling pathway ^[13]
    • immunoglobulin mediated immune response ^{[16, 17]}
    • integrin-mediated signaling pathway ^[10]
    • mast cell activation ^[13]
    • negative regulation of mast cell apoptotic process ^[13]
    • neutrophil activation involved in immune response ^[10]
    • neutrophil chemotaxis ^{[4, 6, 15]}
    • phagocytosis, engulfment ^{[1, 2, 7]}
    • positive regulation of immune response ^[16]
    • positive regulation of interleukin-10 production ^[8]
    • positive regulation of interleukin-6 production ^[13]
    • positive regulation of mast cell cytokine production ^[13]
    • positive regulation of mast cell degranulation ^[13]
    • positive regulation of phagocytosis ^{[1, 2, 7]}
    • positive regulation of tumor necrosis factor production ^{[6, 13]}
    • positive regulation of type I hypersensitivity ^[13]
    • positive regulation of type IIa hypersensitivity ^{[1, 8, 15]}
    • positive regulation of type III hypersensitivity ^[15]
    • regulation of immune response ^[8]
    • regulation of platelet activation ^[11]
    • serotonin secretion by platelet ^[11]
  • performs the following molecular functions:
    • IgE binding ^[13]
    • IgE receptor activity ^[13]
    • IgG binding ^[17]
  • is located in the following cellular components:
    • Fc-epsilon receptor I complex ^[13]

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Summary text based on GO annotations supported by structural data

• Fcer1g encodes a protein or proteins that contain the following InterPro domains: Phosphorylated immunoreceptor signaling ITAM, T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit, indicating that the gene product:
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fcer1g indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Azeredo da Silveira S et al. (2002) Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med, 195:665-72. (PubMed:11901193)
2. Barnes N et al. (2002) FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Immunity, 16:379-89. (PubMed:11911823)
3. Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene, 13:2595-605. (PubMed:9000133)
4. Coxon A et al. (2001) Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity, 14:693-704. (PubMed:11420040)
5. Craig AW et al. (2002) Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol, 22:6363-74. (PubMed:12192036)
6. Heller T et al. (1999) Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis. J Immunol, 162:5657-61. (PubMed:10229794)
7. Hellwig SM et al. (2001) Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis. J Infect Dis, 183:871-9. (PubMed:11237803)
8. Ioan-Facsinay A et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity, 16:391-402. (PubMed:11911824)
9. Kumagai H et al. (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun, 307:719-29. (PubMed:12893283)
10. Mocsai A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol, 7:1326-33. (PubMed:17086186)
11. Poole A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J, 16:2333-41. (PubMed:9171347)
12. Ra C et al. (1989) Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J Biol Chem, 264:15323-7. (PubMed:2527850)
13. Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol, 172:2374-81. (PubMed:14764707)
14. Sato K et al. (2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem, 281:38854-66. (PubMed:17050534)
15. Sylvestre D et al. (1996) Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med, 184:2385-92. (PubMed:8976192)
16. Wernersson S et al. (1999) IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol, 163:618-22. (PubMed:10395649)
17. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:21-32. (PubMed:14643301)
18. Yamasaki S et al. (2008) Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol, 9:1179-88. (PubMed:18776906)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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