About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
MGI:95410

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Erbb2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Beguelin W et al. (2010) Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol, 30:5456-72. (PubMed:20876300)
  2. Borg JP et al. (2000) ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol, 2:407-14. (PubMed:10878805)
  3. Brown N et al. (2004) Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod, 71:2003-11. (PubMed:15306553)
  4. Chan R et al. (2004) Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development, 131:5551-60. (PubMed:15496447)
  5. Chang X et al. (2005) The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med, 202:1141-51. (PubMed:16230479)
  6. Erickson SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development, 124:4999-5011. (PubMed:9362461)
  7. Fu AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci, 4:374-81. (PubMed:11276227)
  8. Garratt AN et al. (2000) A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol, 148:1035-46. (PubMed:10704452)
  9. Gobert RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol, 29:1538-53. (PubMed:19139271)
  10. Gouttenoire EA et al. (2013) Sh3tc2 deficiency affects neuregulin-1/ErbB signaling. Glia, 61:1041-51. (PubMed:23553667)
  11. Kwon HS et al. (2013) Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. J Biol Chem, 288:26357-71. (PubMed:23897819)
  12. Lin W et al. (2000) Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc Natl Acad Sci U S A, 97:1299-304. (PubMed:10655525)
  13. Negishi-Koga T et al. (2011) Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med, 17:1473-80. (PubMed:22019888)
  14. Ozcelik C et al. (2002) Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A, 99:8880-5. (PubMed:12072561)
  15. Sakamoto K et al. (2010) Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene, 29:5359-69. (PubMed:20639901)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory