About   Help   FAQ
Gene Ontology Classifications
dopamine receptor D3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Drd3. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 17, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Accili D et al. (1996) A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci U S A, 93:1945-9. (PubMed:8700864)
  2. Asico LD et al. (1998) Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest, 102:493-8. (PubMed:9691085)
  3. Baik JH et al. (1995) Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature, 377:424-8. (PubMed:7566118)
  4. Basile M et al. (2006) Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. Arch Biochem Biophys, 446:60-8. (PubMed:16386234)
  5. Beaulieu JM et al. (2007) Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci, 27:881-5. (PubMed:17251429)
  6. Bongarzone ER et al. (1998) Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. J Neurosci, 18:5344-53. (PubMed:9651217)
  7. Carta AR et al. (2000) Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient mice. Neuroreport, 11:2395-9. (PubMed:10943692)
  8. Clemens S et al. (2005) Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of dopamine D3 receptor knockout mice. Neuroscience, 133:353-7. (PubMed:15878801)
  9. Clemens S et al. (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci, 24:11337-45. (PubMed:15601940)
  10. Demotes-Mainard J et al. (1996) Postnatal ontogeny of dopamine D3 receptors in the mouse brain: autoradiographic evidence for a transient cortical expression. Brain Res Dev Brain Res, 94:166-74. (PubMed:8836575)
  11. Fishburn CS et al. (1993) A novel short isoform of the D3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop. J Biol Chem, 268:5872-8. (PubMed:8449953)
  12. Glickstein SB et al. (2002) Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J Neurosci, 22:5619-29. (PubMed:12097513)
  13. Joseph JD et al. (2002) Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. Neuroscience, 112:39-49. (PubMed:12044470)
  14. Karasinska JM et al. (2005) Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation. Eur J Neurosci, 22:1741-50. (PubMed:16197514)
  15. Karasinska JM et al. (2000) Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors. Eur J Pharmacol, 399:171-81. (PubMed:10884517)
  16. Koeltzow TE et al. (1998) Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J Neurosci, 18:2231-8. (PubMed:9482807)
  17. McQuade JA et al. (2004) High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene. Behav Brain Res, 151:313-9. (PubMed:15084447)
  18. Mizuo K et al. (2004) Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor. Neurosci Lett, 358:13-6. (PubMed:15016423)
  19. Narita M et al. (2002) Intensification of the development of ethanol dependence in mice lacking dopamine D(3) receptor. Neurosci Lett, 324:129-32. (PubMed:11988344)
  20. Narita M et al. (2003) Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion. J Neurosci, 23:1006-12. (PubMed:12574430)
  21. Pilla M et al. (1999) Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Nature, 400:371-5. (PubMed:10432116)
  22. Steiner H et al. (1997) D3 dopamine receptor-deficient mouse: evidence for reduced anxiety. Physiol Behav, 63:137-41. (PubMed:9402626)
  23. Vallone D et al. (2002) Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice. Behav Brain Res, 130:141-8. (PubMed:11864730)
  24. Wong JY et al. (2003) Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors. Psychopharmacology (Berl), 167:167-73. (PubMed:12652349)
  25. Xu M et al. (1997) Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron, 19:837-48. (PubMed:9354330)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory