GO Annotations Graph

• Symbol: Drd3
• Name: dopamine receptor D3
• ID: MGI:94925

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	IEA	J:72247
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:155856
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:164563
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA	J:265628
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:32128
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:29045
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	J:34152
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:106395
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:263423
Cellular Component	GO:0098691	dopaminergic synapse	EXP	J:263423
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:48510
Cellular Component	GO:0016020	membrane	IDA	J:48510
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:106395
Cellular Component	GO:0005886	plasma membrane	IDA	J:48510
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Biological Process	GO:0046717	acid secretion	ISO	J:155856
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	J:106395
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050482	arachidonic acid secretion	ISO	J:164563
Biological Process	GO:0006914	autophagy	ISO	J:155856
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:156078
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:104271
Biological Process	GO:0007212	dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0007212	dopamine receptor signaling pathway	IMP	J:107534
Biological Process	GO:0007212	dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035483	gastric emptying	ISO	J:155856
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0007626	locomotory behavior	IGI	J:43791
Biological Process	GO:0007626	locomotory behavior	IMP	J:32128
Biological Process	GO:0007626	locomotory behavior	IGI	J:102600
Biological Process	GO:0007626	locomotory behavior	IMP	J:44685
Biological Process	GO:0007626	locomotory behavior	IGI	J:43791
Biological Process	GO:0007626	locomotory behavior	IGI	J:81915
Biological Process	GO:0050883	musculoskeletal movement, spinal reflex action	IMP	J:96803
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045776	negative regulation of blood pressure	IMP	J:115136
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	IGI	J:109223
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IDA	J:48510
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:117785
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0032416	negative regulation of sodium:proton antiporter activity	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0048709	oligodendrocyte differentiation	IDA	J:48510
Biological Process	GO:0048709	oligodendrocyte differentiation	IDA	J:48510
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	J:265628
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	IMP	J:107534
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0060134	prepulse inhibition	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:117785
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	IGI	J:115136
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	IMP	J:115136
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	ISO	J:155856
Biological Process	GO:0014059	regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0014059	regulation of dopamine secretion	IMP	J:46772
Biological Process	GO:0014059	regulation of dopamine secretion	IMP	J:117918
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:89345
Biological Process	GO:0040012	regulation of locomotion	ISO	J:155856
Biological Process	GO:0090325	regulation of locomotion involved in locomotory behavior	ISO	J:155856
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:89345
Biological Process	GO:0051580	regulation of neurotransmitter uptake	IDA	J:263423
Biological Process	GO:0051580	regulation of neurotransmitter uptake	EXP	J:263423
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:0001975	response to amphetamine	IGI	J:109223
Biological Process	GO:0001975	response to amphetamine	IGI	J:109223
Biological Process	GO:0042220	response to cocaine	IMP	J:103704
Biological Process	GO:0045471	response to ethanol	IMP	J:107932
Biological Process	GO:0034776	response to histamine	ISO	J:164563
Biological Process	GO:0043278	response to morphine	IMP	J:81915
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0008542	visual learning	IMP	J:109223