Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc6a3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc6a3
  • participates in the following biological processes:
    • response to cocaine ^[1]
  • performs the following molecular functions:
    • dopamine binding ^[1]
  • is located in the following cellular components:
    • axon ^[5]
• Researchers have inferred, based on physical interactions, that the gene product of Slc6a3
  • performs the following molecular functions:
    • protein N-terminus binding ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc6a3
  • participates in the following biological processes:
    • adenohypophysis development ^[2]
    • dopamine biosynthetic process ^[4]
    • dopamine catabolic process ^[4]
    • dopamine transport ^[4]
    • lactation ^[2]
    • locomotory behavior ^[6]
    • positive regulation of multicellular organism growth ^[2]
    • prepulse inhibition ^[6]
    • regulation of dopamine metabolic process ^{[2, 4]}
    • sensory perception of smell ^[7]
    • transmembrane transport ^[4]
  • performs the following molecular functions:
    • dopamine transmembrane transporter activity ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Slc6a3
  • participates in the following biological processes:
    • locomotory behavior based on interactions with Drd1a, Drd2 ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc6a3:
  • participates in the following biological processes:
    • dopamine transport
    • monoamine transport
    • response to cAMP
    • response to ethanol
  • performs the following molecular functions:
    • dopamine transmembrane transporter activity
    • dopamine:sodium symporter activity
    • drug binding
    • monoamine transmembrane transporter activity
    • protease binding
    • protein complex binding
    • receptor binding
  • is located in the following cellular components:
    • axon
    • neuron projection
    • neuronal cell body
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc6a3 encodes a protein or proteins that contain the following InterPro domains: Sodium:neurotransmitter symporter, Sodium:neurotransmitter symporter, dopamine, indicating that the gene product:
  • participates in the following biological processes:
    • neurotransmitter transport
  • performs the following molecular functions:
    • neurotransmitter:sodium symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • integral to plasma membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc6a3 indicates that it:
  • participates in the following biological processes:
    • neurotransmitter transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Bailey A et al. (2008) Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. Eur J Neurosci, 28:759-70. (PubMed:18671743)
2. Bosse R et al. (1997) Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron, 19:127-38. (PubMed:9247269)
3. Egana LA et al. (2009) Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J Neurosci, 29:4592-604. (PubMed:19357284)
4. Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A, 95:4029-34. (PubMed:9520487)
5. Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science, 317:1220-4. (PubMed:17761882)
6. Ralph RJ et al. (2001) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J Neurosci, 21:305-13. (PubMed:11150348)
7. Tillerson JL et al. (2006) Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behav Brain Res, 172:97-105. (PubMed:16765459)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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