Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Predicted to act upstream of or within several processes, including blood coagulation; complement activation, classical pathway; and fibrinolysis. Located in extracellular space. Is expressed in several structures, including genitourinary system; neural ectoderm; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1).