Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyr61. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 22, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyr61
  • participates in the following biological processes:
    • cell adhesion ^[2]
    • cell-cell adhesion ^[7]
    • chondroblast differentiation ^[7]
    • extracellular matrix organization ^[3]
    • positive regulation of cell differentiation ^[7]
    • positive regulation of cell migration ^[6]
    • positive regulation of cell-substrate adhesion ^[3]
    • positive regulation of ceramide biosynthetic process ^[1]
    • positive regulation of phospholipase activity ^[1]
    • reactive oxygen species metabolic process ^[1]
  • performs the following molecular functions:
    • extracellular matrix binding ^[3]
    • integrin binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cyr61
  • participates in the following biological processes:
    • apoptotic process involved in heart morphogenesis ^[4]
    • atrial septum morphogenesis ^[4]
    • atrioventricular valve morphogenesis ^[4]
    • chorio-allantoic fusion ^[5]
    • intussusceptive angiogenesis ^[5]
    • labyrinthine layer blood vessel development ^[5]
    • negative regulation of apoptotic process ^[4]
    • positive regulation of cartilage development ^[7]
    • ventricular septum development ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Cyr61
  • participates in the following biological processes:
    • osteoblast differentiation based on interactions with Wnt3a ^[6]
    • positive regulation of apoptotic process based on interactions with ^[1]
    • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process based on interactions with ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyr61:
  • participates in the following biological processes:
    • cell adhesion
    • chemotaxis
    • positive regulation of BMP signaling pathway
    • positive regulation of cell migration
    • positive regulation of osteoblast differentiation
    • positive regulation of osteoblast proliferation
    • positive regulation of protein kinase activity
    • positive regulation of protein phosphorylation
    • positive regulation of transcription from RNA polymerase II promoter
    • regulation of ERK1 and ERK2 cascade
    • wound healing, spreading of cells

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Summary text based on GO annotations supported by structural data

• Cyr61 encodes a protein or proteins that contain the following InterPro domains: Cystine knot, Cystine knot, C-terminal, IGFBP-related, CNN, Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, Insulin-like growth factor-binding protein, IGFBP, Thrombospondin, type 1 repeat, von Willebrand factor, type C, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of cell growth
  • performs the following molecular functions:
    • insulin-like growth factor binding
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyr61 indicates that it:
  • performs the following molecular functions:
    • growth factor binding
    • heparin binding
  • is located in the following cellular components:
    • extracellular region

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References

1. Juric V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol, 29:3266-79. (PubMed:19364818)
2. Leu SJ et al. (2003) Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). J Biol Chem, 278:33801-8. (PubMed:12826661)
3. Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A, 105:12849-54. (PubMed:18757743)
4. Mo FE et al. (2006) The matricellular protein CCN1 is essential for cardiac development. Circ Res, 99:961-9. (PubMed:17023674)
5. Mo FE et al. (2002) CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity. Mol Cell Biol, 22:8709-20. (PubMed:12446788)
6. Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol, 26:2955-64. (PubMed:16581771)
7. Wong M et al. (1997) Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol, 192:492-508. (PubMed:9441684)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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