Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyp19a1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyp19a1
  • participates in the following biological processes:
    • oxidation-reduction process ^[2]
  • performs the following molecular functions:
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cyp19a1
  • participates in the following biological processes:
    • androgen metabolic process ^[3]
    • prostate gland growth ^{[1, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyp19a1:
  • participates in the following biological processes:
    • androgen metabolic process
    • C21-steroid hormone metabolic process
    • estrogen biosynthetic process
    • oxidation-reduction process
    • regulation of synapse structure and activity
  • performs the following molecular functions:
    • aromatase activity
    • heme binding
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
  • is located in the following cellular components:
    • axon terminus
    • cytoplasm
    • cytosol
    • dendritic spine
    • endoplasmic reticulum
    • neuronal cell body
    • synapse
    • synaptic vesicle
    • terminal button

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Summary text based on GO annotations supported by structural data

• Cyp19a1 encodes a protein or proteins that contain the following InterPro domains: Cytochrome P450, Cytochrome P450, conserved site, Cytochrome P450, E-class, group I, indicating that the gene product:
  • performs the following molecular functions:
    • electron carrier activity
    • iron ion binding
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyp19a1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane

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References

1. Bianco JJ et al. (2006) Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life. Am J Pathol, 168:1869-78. (PubMed:16723702)
2. Gray SA et al. (1995) Development of cytochrome P450 aromatase mRNA levels and enzyme activity in ovaries of normal and hypogonadal (hpg) mice. J Mol Endocrinol, 14:295-301. (PubMed:7669221)
3. McPherson SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology, 142:2458-67. (PubMed:11356695)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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