Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cybb. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cybb
  • is located in the following cellular components:
    • cytoplasm ^{[2, 4]}
    • mitochondrion ^[3]
    • plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cybb
  • participates in the following biological processes:
    • hydrogen peroxide biosynthetic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cybb:
  • participates in the following biological processes:
    • innate immune response
    • oxidation-reduction process
    • respiratory burst
    • response to drug
    • superoxide anion generation
    • superoxide metabolic process
  • performs the following molecular functions:
    • flavin adenine dinucleotide binding
    • heme binding
    • protein heterodimerization activity
  • is located in the following cellular components:
    • dendrite
    • endoplasmic reticulum
    • Golgi apparatus
    • integral to plasma membrane
    • intracellular
    • NADPH oxidase complex
    • neuronal cell body
    • plasma membrane
    • rough endoplasmic reticulum

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Summary text based on GO annotations supported by structural data

• Cybb encodes a protein or proteins that contain the following InterPro domains: Cytochrome b245, heavy chain, FAD-binding 8, Ferredoxin reductase-type FAD-binding domain, Ferric reductase transmembrane component-like domain, Ferric reductase, NAD binding, Riboflavin synthase-like beta-barrel, indicating that the gene product:
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cybb indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • ion transport
    • regulation of ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • metal ion binding
    • oxidoreductase activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Jackson SH et al. (2004) T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol, 5:818-27. (PubMed:15258578)
2. Kazama K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res, 95:1019-26. (PubMed:15499027)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Shukla S et al. (2005) Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Biochem Biophys Res Commun, 331:476-83. (PubMed:15850784)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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