Automated description from the Alliance of Genome Resources
Exhibits superoxide-generating NADPH oxidase activity. Predicted to contribute to electron transfer activity. Involved in several processes, including hydrogen peroxide biosynthetic process; innate immune response; and superoxide metabolic process. Localizes to the NADPH oxidase complex and phagocytic vesicle. Predicted to colocalize with the perinuclear endoplasmic reticulum. Used to study chronic granulomatous disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and primary immunodeficiency disease. Orthologous to human CYBB (cytochrome b-245 beta chain).