Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cd4
  • participates in the following biological processes:
    • cell surface receptor signaling pathway ^[40]
    • positive regulation of calcium-mediated signaling ^[40]
    • positive regulation of peptidyl-tyrosine phosphorylation ^[40]
    • positive regulation of T cell activation ^[42]
  • is located in the following cellular components:
    • cell surface ^[28]
    • endoplasmic reticulum lumen ^[18]
    • endoplasmic reticulum membrane ^[18]
    • external side of plasma membrane ^{[1, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44]}
    • membrane raft ^[2]
    • plasma membrane ^[33]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cd4
  • participates in the following biological processes:
    • cytokine production ^[3]
    • defense response to Gram-negative bacterium ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Cd4
  • participates in the following biological processes:
    • cytokine production based on interactions with Foxp3 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cd4:
  • participates in the following biological processes:
    • induction by virus of host cell-cell fusion
    • maintenance of protein location in cell
    • positive regulation of protein kinase activity
    • protein palmitoleylation
    • regulation of T cell activation
    • T cell activation
    • T cell differentiation
    • T cell selection
  • performs the following molecular functions:
    • enzyme binding
    • glycoprotein binding
    • protein homodimerization activity
    • protein kinase binding
    • zinc ion binding
  • is located in the following cellular components:
    • external side of plasma membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Cd4 encodes a protein or proteins that contain the following InterPro domains: CD4, extracellular, Immunoglobulin, Immunoglobulin C2-set, Immunoglobulin subtype, Immunoglobulin V-set, subgroup, Immunoglobulin-like, Immunoglobulin-like fold, T cell CD4 receptor C-terminal region, T-cell surface antigen CD4, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • immune response
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cd4 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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