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Gene Ontology Classifications
CD4 antigen

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
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  2. Balamuth F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol, 172:5887-92. (PubMed:15128768)
  3. Blair PJ et al. (1994) CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol, 153:3764-74. (PubMed:7930593)
  4. Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A, 93:7877-81. (PubMed:8755570)
  5. Bry L et al. (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol, 172:433-41. (PubMed:14688352)
  6. Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev, 19:2849-61. (PubMed:16287714)
  7. Campbell KS et al. (1995) Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8 alpha in yeast. Eur J Immunol, 25:2408-12. (PubMed:7664803)
  8. Campbell KS et al. (1995) Interaction of p56lck with CD4 in the yeast two-hybrid system. Ann N Y Acad Sci, 766:89-92. (PubMed:7486703)
  9. Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature, 378:303-6. (PubMed:7477353)
  10. Chu K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A, 92:11894-8. (PubMed:8524870)
  11. Du C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 10:1252-9. (PubMed:19838199)
  12. Garcia-Martinez LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol, 173:2995-3001. (PubMed:15322158)
  13. Gartlan KH et al. (2010) A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol, 185:3158-66. (PubMed:20709950)
  14. Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity, 5:181-8. (PubMed:8769481)
  15. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med, 206:2987-3000. (PubMed:19934022)
  16. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood, 117:6120-31. (PubMed:21508411)
  17. Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice [see comments] J Exp Med, 191:771-80. (PubMed:10704459)
  18. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol, 177:6650-9. (PubMed:17082577)
  19. Kisielow J et al. (2008) SCART scavenger receptors identify a novel subset of adult gammadelta T cells. J Immunol, 181:1710-6. (PubMed:18641307)
  20. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ, 7:107-14. (PubMed:8788039)
  21. Liden M et al. (2005) The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Exp Cell Res, 311:205-17. (PubMed:16223484)
  22. Ling KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol, 37:1043-52. (PubMed:17357106)
  23. Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med, 201:603-14. (PubMed:15728238)
  24. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity, 25:441-54. (PubMed:16973387)
  25. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol, 224:98-105. (PubMed:14609575)
  26. Mendiratta SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity, 6:469-477. (PubMed:9133426)
  27. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity, 10:249-59. (PubMed:10072077)
  28. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
  29. Negishi I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature, 376:435-8. (PubMed:7630421)
  30. Nowell CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet, 7:e1002348. (PubMed:22072979)
  31. Sant'Angelo DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity, 4:367-76. (PubMed:8612131)
  32. Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science, 261:609-12. (PubMed:7688139)
  33. Shiow LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol, 9:1307-15. (PubMed:18836449)
  34. Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol, 25:2618-25. (PubMed:7589135)
  35. Stone EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol, 29:3770-82. (PubMed:19349303)
  36. Suzuki M et al. (2003) Microfilament-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem, 278:51448-53. (PubMed:14517216)
  37. Takayanagi S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood, 107:4317-25. (PubMed:16455951)
  38. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis Cell, 102:221-31. (PubMed:10943842)
  39. Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab, 10:229-40. (PubMed:19723499)
  40. Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature, 378:298-302. (PubMed:7477352)
  41. Van Laethem F et al. (2013) Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell, 154:1326-41. (PubMed:24034254)
  42. Wang L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol, 40:2385-90. (PubMed:20706986)
  43. Wang L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol, 9:1122-30. (PubMed:18776904)
  44. Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity, 6:663-71. (PubMed:9208839)
  45. Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med, 201:1077-88. (PubMed:15795238)
  46. Workman CJ et al. (2002) Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol, 169:5392-5. (PubMed:12421911)
  47. Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity, 32:507-17. (PubMed:20399120)
  48. Ye Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol, 34:2750. (PubMed:15368291)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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