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Gene Ontology Classifications
CD24a antigen

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cd24a. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 13, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aigner S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol, 7:1557-65. (PubMed:8562500)
  2. Arimitsu N et al. (2003) Glycophorin A requirement for expression of O-linked antigens on the erythrocyte membrane. Genes Cells, 8:769-77. (PubMed:12940824)
  3. Bai XF et al. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J Clin Invest, 105:1227-32. (PubMed:10791997)
  4. Bai XF et al. (2004) CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med, 200:447-58. (PubMed:15314074)
  5. Belvindrah R et al. (2002) Increased neurogenesis in adult mCD24-deficient mice. J Neurosci, 22:3594-607. (PubMed:11978835)
  6. Carlyle JR et al. (2004) Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A, 101:3527-32. (PubMed:14990792)
  7. Chappel MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med, 184:1638-49. (PubMed:8920854)
  8. Chen C et al. (2004) Inhibition of human CD24 binding to platelet-bound P-selectin by monoclonal antibody. Proc West Pharmacol Soc, 47:28-9. (PubMed:15633604)
  9. Cram DS et al. (1999) Differential mRNA display analysis of two related but functionally distinct rat insulinoma (RIN) cell lines: identification of CD24 and its expression in the developing pancreas. Differentiation, 64:237-46. (PubMed:10365441)
  10. Enk AH et al. (1994) Heat-stable antigen is an important costimulatory molecule on epidermal Langerhans' cells. J Immunol, 152:3264-70. (PubMed:7908303)
  11. Gekara NO et al. (2004) Lipid rafts clustering and signalling by listeriolysin O. Biochem Soc Trans, 32:712-4. (PubMed:15493995)
  12. Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol, 15:937-44. (PubMed:12882831)
  13. Greene SB et al. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci, 123:606-18. (PubMed:20103531)
  14. Gu B et al. (2009) Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol, 185:811-26. (PubMed:19487454)
  15. Hahne M et al. (1994) The heat-stable antigen can alter very late antigen 4-mediated adhesion. J Exp Med, 179:1391-5. (PubMed:8145052)
  16. Hitsumoto Y et al. (1996) Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology, 89:200-4. (PubMed:8943715)
  17. Hough MR et al. (1996) Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen. J Immunol, 156:479-88. (PubMed:8543797)
  18. Hubbe M et al. (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol, 24:731-7. (PubMed:8125140)
  19. Jevsek M et al. (2006) CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc Natl Acad Sci U S A, 103:6374-9. (PubMed:16606832)
  20. Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol, 38:2806-20. (PubMed:18958875)
  21. Jung KC et al. (2004) TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J Immunol, 172:795-802. (PubMed:14707049)
  22. Kadmon G et al. (1995) Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons. Eur J Neurosci, 7:993-1004. (PubMed:7613634)
  23. Kadmon G et al. (1995) Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun, 214:94-101. (PubMed:7669058)
  24. Kadmon G et al. (1994) Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction. Biochem Biophys Res Commun, 198:1209-15. (PubMed:8117278)
  25. Kato K et al. (1992) CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med, 176:1241-9. (PubMed:1383383)
  26. Kawai K et al. (1995) Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med, 181:345-9. (PubMed:7807014)
  27. Kay R et al. (1990) Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens. J Immunol, 145:1952-9. (PubMed:2118158)
  28. Kilger G et al. (1995) Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1. J Biol Chem, 270:5979-84. (PubMed:7534304)
  29. Kleene R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem, 276:21656-63. (PubMed:11283023)
  30. Krauss K et al. (1999) Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J Biol Chem, 274:36921-7. (PubMed:10601245)
  31. Lesourne R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol, 189:1154-61. (PubMed:22732588)
  32. Li O et al. (2006) Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med, 203:1713-20. (PubMed:16769998)
  33. Li O et al. (2004) CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med, 200:1083-9. (PubMed:15477346)
  34. Lieberoth A et al. (2009) Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci, 29:6677-90. (PubMed:19458237)
  35. Liu Y et al. (1992) Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol, 22:2855-9. (PubMed:1385153)
  36. Liu Y et al. (1992) Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med, 175:437-45. (PubMed:1346270)
  37. Nielsen PJ et al. (1997) Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood, 89:1058-67. (PubMed:9028339)
  38. Nieoullon V et al. (2005) mCD24 regulates proliferation of neuronal committed precursors in the subventricular zone. Mol Cell Neurosci, 28:462-74. (PubMed:15737737)
  39. Ruppert M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol, 131:1881-91. (PubMed:8557754)
  40. Sammar M et al. (1997) Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1. Biochim Biophys Acta, 1337:287-94. (PubMed:9048906)
  41. Sammar M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun, 234:330-4. (PubMed:9177270)
  42. Sammar M et al. (1994) Heat-stable antigen (CD24) as ligand for mouse P-selectin. Int Immunol, 6:1027-36. (PubMed:7524641)
  43. Schabath H et al. (2006) CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. J Cell Sci, 119:314-25. (PubMed:16390867)
  44. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis Cell, 102:221-31. (PubMed:10943842)
  45. Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature, 378:298-302. (PubMed:7477352)
  46. Wang L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol, 9:1122-30. (PubMed:18776904)
  47. Wang YC et al. (1995) Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice. Eur J Immunol, 25:1163-7. (PubMed:7774619)
  48. Wenger RH et al. (1995) B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Res, 4:173-83. (PubMed:7795661)
  49. Yoder MC et al. (1997) Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity, 7:335-44. (PubMed:9324354)
  50. Zhou Q et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur J Immunol, 27:2524-8. (PubMed:9368605)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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