Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Car2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Car2
  • is located in the following cellular components:
    • cytosol ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Car2
  • participates in the following biological processes:
    • carbon dioxide transport ^[2]
    • morphogenesis of an epithelium ^[2]
    • secretion ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Car2:
  • participates in the following biological processes:
    • positive regulation of bone resorption
    • positive regulation of cellular pH reduction
    • positive regulation of osteoclast differentiation
  • performs the following molecular functions:
    • carbonate dehydratase activity
    • zinc ion binding
  • is located in the following cellular components:
    • apical part of cell
    • axon
    • basolateral plasma membrane
    • cytoplasm
    • extracellular space
    • microvillus

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Summary text based on GO annotations supported by structural data

• Car2 encodes a protein or proteins that contain the following InterPro domains: Alpha carbonic anhydrase, Carbonic anhydrase, alpha-class, Carbonic anhydrase, alpha-class, conserved site, Carbonic anhydrase, CA-II, indicating that the gene product:
  • participates in the following biological processes:
    • one-carbon metabolic process

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Car2 indicates that it:
  • performs the following molecular functions:
    • lyase activity
    • metal ion binding

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References

1. Dou H et al. (2004) Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac. J Histochem Cytochem, 52:1377-84. (PubMed:15385584)
2. Leppilampi M et al. (2005) Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proc Natl Acad Sci U S A, 102:15247-52. (PubMed:16217040)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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