GO Annotations Graph

• Symbol: Car2
• Name: carbonic anhydrase 2
• ID: MGI:88269

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004064	arylesterase activity	ISO	J:164563
Molecular Function	GO:0004089	carbonate dehydratase activity	ISO	J:155856
Molecular Function	GO:0004089	carbonate dehydratase activity	ISO	J:164563
Molecular Function	GO:0004089	carbonate dehydratase activity	IBA	J:265628
Molecular Function	GO:0004089	carbonate dehydratase activity	IMP	J:200079
Molecular Function	GO:0004089	carbonate dehydratase activity	IDA	J:88968
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:326271
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:150397
Cellular Component	GO:0005829	cytosol	IDA	J:200079
Cellular Component	GO:0005829	cytosol	IDA	J:216097
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005902	microvillus	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043209	myelin sheath	IDA	J:127436
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0038166	angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:0015670	carbon dioxide transport	IBA	J:265628
Biological Process	GO:0015670	carbon dioxide transport	IMP	J:102478
Biological Process	GO:0015670	carbon dioxide transport	IC	J:88968
Biological Process	GO:0002009	morphogenesis of an epithelium	IMP	J:102478
Biological Process	GO:0070050	neuron cellular homeostasis	IMP	J:200079
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0032849	positive regulation of cellular pH reduction	ISO	J:155856
Biological Process	GO:0032849	positive regulation of cellular pH reduction	IMP	J:200079
Biological Process	GO:2001150	positive regulation of dipeptide transmembrane transport	IMP	J:159253
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	IGI	J:200079
Biological Process	GO:2001225	regulation of chloride transport	IMP	J:200079
Biological Process	GO:0051453	regulation of intracellular pH	IMP	J:159253
Biological Process	GO:0044070	regulation of monoatomic anion transport	ISO	J:164563
Biological Process	GO:0006885	regulation of pH	IC	J:88968
Biological Process	GO:0046903	secretion	IMP	J:102478