Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of C2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

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Summary text based on GO annotations supported by structural data

• C2 encodes a protein or proteins that contain the following InterPro domains: Complement B/C2, Complement control module, Peptidase cysteine/serine, trypsin-like, Peptidase S1/S6, chymotrypsin/Hap, Peptidase S1/S6, chymotrypsin/Hap, active site, Peptidase S1A, chymotrypsin-type, Sushi/SCR/CCP, von Willebrand factor, type A, indicating that the gene product:
  • participates in the following biological processes:
    • complement activation
    • proteolysis
  • performs the following molecular functions:
    • catalytic activity
    • serine-type endopeptidase activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe C2 indicates that it:
  • participates in the following biological processes:
    • complement activation, classical pathway
    • innate immune response
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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