Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmp5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Bmp5 has been shown to bind to the gene products of Chrdl2. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bmp5
  • participates in the following biological processes:
    • pattern specification process ^[1]
    • skeletal system development ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Bmp5
  • participates in the following biological processes:
    • male genitalia development based on interactions with Bmp6 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bmp5:
  • participates in the following biological processes:
    • negative regulation of aldosterone biosynthetic process
    • negative regulation of cell proliferation
    • negative regulation of cortisol biosynthetic process
    • negative regulation of insulin-like growth factor receptor signaling pathway
    • negative regulation of steroid biosynthetic process
    • positive regulation of dendrite development
    • positive regulation of DNA-dependent DNA replication
    • positive regulation of epithelial cell proliferation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of transcription from RNA polymerase II promoter
    • type B pancreatic cell development
  • performs the following molecular functions:
    • BMP receptor binding
  • is located in the following cellular components:
    • extracellular space
    • membrane-bounded vesicle

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Summary text based on GO annotations supported by structural data

• Bmp5 encodes a protein or proteins that contain the following InterPro domains: Transforming growth factor beta, conserved site, Transforming growth factor-beta, C-terminal, Transforming growth factor-beta, N-terminal, Transforming growth factor-beta-related, indicating that the gene product:
  • participates in the following biological processes:
    • growth
  • performs the following molecular functions:
    • growth factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bmp5 indicates that it:
  • participates in the following biological processes:
    • cartilage development
    • cell differentiation
    • multicellular organismal development
    • ossification
  • performs the following molecular functions:
    • cytokine activity
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Kingsley DM et al. (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell, 71:399-410. (PubMed:1339316)
2. Nakayama N et al. (2004) A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development, 131:229-40. (PubMed:14660436)
3. Solloway MJ et al. (1998) Mice lacking Bmp6 function. Dev Genet, 22:321-39. (PubMed:9664685)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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