About   Help   FAQ
Gene Ontology Classifications
brain derived neurotrophic factor

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bdnf. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Biffo S et al. (1990) B-50/GAP43 Expression Correlates with Process Outgrowth in the Embryonic Mouse Nervous System. Eur J Neurosci, 2:487-499. (PubMed:12106019)
  2. Bloodgood BL et al. (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature, 503:121-5. (PubMed:24201284)
  3. Cheng A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol, 258:319-33. (PubMed:12798291)
  4. Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development, 128:4315-27. (PubMed:11684666)
  5. Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14:1153-64. (PubMed:7605630)
  6. Fritzsch B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn, 233:570-83. (PubMed:15844198)
  7. Gauthier LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118:127-38. (PubMed:15242649)
  8. Gorski JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci, 23:6856-65. (PubMed:12890780)
  9. Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci, 21:2019-23. (PubMed:15869495)
  10. Hellard D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol, 275:34-43. (PubMed:15464571)
  11. Huang T et al. (2014) BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol, 386:308-20. (PubMed:24378336)
  12. Kanematsu T et al. (2006) Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J Biol Chem, 281:22180-9. (PubMed:16754670)
  13. Kimura A et al. (2015) Valproic Acid Prevents NMDA-Induced Retinal Ganglion Cell Death via Stimulation of Neuronal TrkB Receptor Signaling. Am J Pathol, 185:756-64. (PubMed:25542970)
  14. Lambert WM et al. (2013) Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol, 33:3700-14. (PubMed:23878391)
  15. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
  16. Lynch G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease J Neurosci, 27:4424-4434. (PubMed:17442827)
  17. Monteggia LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A, 101:10827-32. (PubMed:15249684)
  18. Ng T et al. (2012) Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul Pept, 174:79-89. (PubMed:22209827)
  19. Ouyang Q et al. (2013) Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron, 80:97-112. (PubMed:24035762)
  20. Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci, 24:43-52. (PubMed:14715936)
  21. Sajithlal G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol, 284:323-36. (PubMed:16018995)
  22. Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci, 23:7084-92. (PubMed:12904469)
  23. Sedy J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn, 231:551-63. (PubMed:15376326)
  24. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)
  25. Tessarollo L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci, 24:2575-84. (PubMed:15014133)
  26. Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res, 73:693-701. (PubMed:11747369)
  27. Xu B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci, 6:736-42. (PubMed:12796784)
  28. Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci, 9:1009-18. (PubMed:16819522)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory