Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bdnf. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bdnf
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[15]
    • negative regulation of neuroblast proliferation ^[2]
    • positive regulation of neuron differentiation ^[2]
    • regulation of neuron apoptotic process ^[10]
    • regulation of retinal cell programmed cell death ^[19]
    • regulation of synaptic plasticity ^{[11, 21]}
    • ureteric bud development ^[14]
  • is located in the following cellular components:
    • cytoplasmic membrane-bounded vesicle ^{[6, 13]}
• The gene product of Bdnf has been shown to bind to the gene products of Ngfr. ^[3] Researchers have inferred, based on physical interactions, that the gene product of Bdnf
  • participates in the following biological processes:
    • glutamate secretion ^[21]
  • performs the following molecular functions:
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bdnf
  • participates in the following biological processes:
    • axon guidance ^[18]
    • axon target recognition ^[9]
    • behavior ^[12]
    • dendrite development ^[7]
    • fear response ^[12]
    • feeding behavior ^[20]
    • inner ear development ^[4]
    • learning or memory ^[12]
    • negative regulation of neuron apoptotic process ^{[8, 17]}
    • nerve development ^[4]
    • neuron recognition ^[5]
    • regulation of metabolic process ^[1]
    • response to drug ^[12]
• Researchers have inferred, based on genetic interactions, that the gene product of Bdnf
  • participates in the following biological processes:
    • mechanoreceptor differentiation based on interactions with , ^[16]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bdnf:
  • participates in the following biological processes:
    • mitochondrial electron transport, NADH to ubiquinone
    • negative regulation of striated muscle tissue development
    • nervous system development
    • positive regulation of long-term neuronal synaptic plasticity
    • positive regulation of synapse assembly
    • regulation of excitatory postsynaptic membrane potential
    • regulation of long-term neuronal synaptic plasticity
    • regulation of short-term neuronal synaptic plasticity
  • performs the following molecular functions:
    • neurotrophin TRKB receptor binding
  • is located in the following cellular components:
    • synaptic vesicle

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Summary text based on GO annotations supported by structural data

• Bdnf encodes a protein or proteins that contain the following InterPro domains: Brain-derived neurotrophic factor, Nerve growth factor conserved site, Nerve growth factor-like, Nerve growth factor-related, indicating that the gene product:
  • performs the following molecular functions:
    • receptor binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bdnf indicates that it:
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Biffo S et al. (1990) B-50/GAP43 Expression Correlates with Process Outgrowth in the Embryonic Mouse Nervous System. Eur J Neurosci, 2:487-499. (PubMed:12106019)
2. Cheng A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol, 258:319-33. (PubMed:12798291)
3. Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development, 128:4315-27. (PubMed:11684666)
4. Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14:1153-64. (PubMed:7605630)
5. Fritzsch B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn, 233:570-83. (PubMed:15844198)
6. Gauthier LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118:127-38. (PubMed:15242649)
7. Gorski JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci, 23:6856-65. (PubMed:12890780)
8. Guo H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur J Neurosci, 21:2019-23. (PubMed:15869495)
9. Hellard D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev Biol, 275:34-43. (PubMed:15464571)
10. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
11. Lynch G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease J Neurosci, 27:4424-4434. (PubMed:17442827)
12. Monteggia LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A, 101:10827-32. (PubMed:15249684)
13. Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci, 24:43-52. (PubMed:14715936)
14. Sajithlal G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol, 284:323-36. (PubMed:16018995)
15. Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci, 23:7084-92. (PubMed:12904469)
16. Sedy J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn, 231:551-63. (PubMed:15376326)
17. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)
18. Tessarollo L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci, 24:2575-84. (PubMed:15014133)
19. Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res, 73:693-701. (PubMed:11747369)
20. Xu B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci, 6:736-42. (PubMed:12796784)
21. Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci, 9:1009-18. (PubMed:16819522)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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