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Gene Ontology Classifications
Symbol
Name
ID
Ar
androgen receptor
MGI:88064

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ar. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Abel MH et al. (2008) Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology, 149:3279-85. (PubMed:18403489)
  3. Asadi FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology, 134:1179-87. (PubMed:8119157)
  4. Bagheri-Fam S et al. (2011) Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet, 20:2213-24. (PubMed:21427128)
  5. Balla A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol Reprod, 69:1281-93. (PubMed:12801993)
  6. Chen YH et al. (2005) GAC63, a GRIP1-Dependent Nuclear Receptor Coactivator. Mol Cell Biol, 25:5965-72. (PubMed:15988012)
  7. Donjacour AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol, 261:39-54. (PubMed:12941620)
  8. Gonzalez MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol Cell Endocrinol, 190:39-49. (PubMed:11997177)
  9. Hong CY et al. (2005) Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol Endocrinol, 19:2245-57. (PubMed:15919722)
  10. Jeong BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol Endocrinol, 18:13-25. (PubMed:14576337)
  11. Khan OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol, 20:544-59. (PubMed:16254014)
  12. Krutskikh A et al. (2011) Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology, 152:689-96. (PubMed:21084446)
  13. Lim P et al. (2009) Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology, 150:4755-65. (PubMed:19574395)
  14. Lin HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J, 21:4037-48. (PubMed:12145204)
  15. Lyon MF et al. (1970) X-linked gene for testicular feminization in the mouse. Nature, 227:1217-9. (PubMed:5452809)
  16. Lyssand JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J Biol Chem, 283:18792-800. (PubMed:18468998)
  17. McPherson SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology, 142:2458-67. (PubMed:11356695)
  18. Miyagawa S et al. (2009) Genetic interactions of the Androgen and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol, 23:871-880. (PubMed:19282366)
  19. Morales CR et al. (2000) Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. J Androl, 21:765-75. (PubMed:11105903)
  20. O'Shaughnessy PJ et al. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology, 148:2914-24. (PubMed:17332066)
  21. Qi W et al. (2007) A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression. EMBO J, 26:65-75. (PubMed:17170703)
  22. Sano M et al. (2007) Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab, 5:129-42. (PubMed:17276355)
  23. Simanainen U et al. (2007) Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology, 148:2264-72. (PubMed:17317769)
  24. Sitz JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol, 24:5821-34. (PubMed:15199138)
  25. Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol, 199:489-97. (PubMed:18827067)
  26. Terada K et al. (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J, 24:611-22. (PubMed:15660130)
  27. Wissmann M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol, 9:347-53. (PubMed:17277772)
  28. Wu CT et al. (2007) Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proc Natl Acad Sci U S A, 104:12679-84. (PubMed:17652515)
  29. Yeh S et al. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med, 198:1899-908. (PubMed:14676301)
  30. Yong W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem, 282:5026-36. (PubMed:17142810)
  31. Zimmermann S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol, 13:681-91. (PubMed:10319319)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory