Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including lipid homeostasis; lipoprotein metabolic process; and plasma lipoprotein particle remodeling. Localizes to glutamatergic synapse and low-density lipoprotein particle. Predicted to colocalize with early endosome and microtubule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).