Automated description from the Alliance of Genome Resources
Exhibits several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including lipid homeostasis; lipoprotein metabolic process; and plasma lipoprotein particle remodeling. Localizes to the glutamatergic synapse and low-density lipoprotein particle. Predicted to colocalize with the early endosome and microtubule. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); familial hyperlipidemia (multiple); and neurodegenerative disease (multiple). Orthologous to human APOE (apolipoprotein E).