Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; positive regulation of kidney development; and regulation of systemic arterial blood pressure by renin-angiotensin. Predicted to localize to perinuclear region of cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal failure; hypoglycemia; intellectual disability; and vesicoureteral reflux. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Orthologous to human AGTR2 (angiotensin II receptor type 2).