Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including chondroitin sulfate binding activity; heparan sulfate proteoglycan binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of sodium ion export across plasma membrane; positive regulation of Rac protein signal transduction; and positive regulation of protein modification process. Acts upstream of or within several processes, including positive regulation of motor neuron apoptotic process; positive regulation of transcription by RNA polymerase II; and regulation of synaptic activity. Located in several cellular components, including cell surface; sarcolemma; and synaptic cleft. Is active in extracellular space and synapse. Is expressed in several structures, including epithelium; lower jaw; musculature; nervous system; and retina. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin).