GO Annotations Graph

• Symbol: Agrn
• Name: agrin
• ID: MGI:87961

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030548	acetylcholine receptor regulator activity	IDA	J:86639
Molecular Function	GO:0042030	ATPase inhibitor activity	IDA	J:151007
Molecular Function	GO:0036122	BMP binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0035374	chondroitin sulfate binding	IDA	J:196117
Molecular Function	GO:0002162	dystroglycan binding	ISO	J:155856
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	IDA	J:196117
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:205644
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:151007
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	IDA	J:27732
Cellular Component	GO:0005604	basement membrane	IDA	J:139122
Cellular Component	GO:0009986	cell surface	IDA	J:151007
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-2426638
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-420389
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:78399
Cellular Component	GO:0005615	extracellular space	TAS	J:33098
Cellular Component	GO:0005615	extracellular space	IDA	J:45159
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005796	Golgi lumen	TAS	Reactome:R-MMU-2024090
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0042383	sarcolemma	IDA	J:151007
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:136579
Cellular Component	GO:0045202	synapse	IDA	J:182391
Cellular Component	GO:0045202	synapse	EXP	J:182391
Cellular Component	GO:0043083	synaptic cleft	IDA	J:192104
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IDA	J:33098
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:70506
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1903407	negative regulation of P-type sodium:potassium-exchanging transporter activity	IDA	J:151007
Biological Process	GO:1903277	negative regulation of sodium ion export across plasma membrane	IDA	J:151007
Biological Process	GO:0007528	neuromuscular junction development	IGI	J:78399
Biological Process	GO:0007528	neuromuscular junction development	IGI	J:78399
Biological Process	GO:0007528	neuromuscular junction development	IGI	J:78399
Biological Process	GO:0045213	neurotransmitter receptor metabolic process	IDA	J:86639
Biological Process	GO:0007009	plasma membrane organization	IMP	J:33098
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:2000673	positive regulation of motor neuron apoptotic process	IMP	J:70506
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:205644
Biological Process	GO:2000541	positive regulation of protein geranylgeranylation	IMP	J:86639
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:86639
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IDA	J:151007
Biological Process	GO:0045887	positive regulation of synaptic assembly at neuromuscular junction	IMP	J:55407
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:45159
Biological Process	GO:0015031	protein transport	IDA	J:211088
Biological Process	GO:0043113	receptor clustering	ISO	J:164563
Biological Process	GO:0043113	receptor clustering	IGI	J:78399
Biological Process	GO:0043113	receptor clustering	ISO	J:73065
Biological Process	GO:0043113	receptor clustering	IGI	J:78399
Biological Process	GO:0043113	receptor clustering	IGI	J:78399
Biological Process	GO:0043113	receptor clustering	IDA	J:119654
Biological Process	GO:0043113	receptor clustering	IDA	J:64996
Biological Process	GO:0043113	receptor clustering	IMP	J:69623
Biological Process	GO:1902667	regulation of axon guidance	ISO	J:155856
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	IDA	J:151007
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IDA	J:151007
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:86639
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:155856
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0050807	regulation of synapse organization	ISO	J:155856
Biological Process	GO:0060025	regulation of synaptic activity	IDA	J:211088
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	ISO	J:155856
Biological Process	GO:0007416	synapse assembly	ISO	J:155856