Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chrna5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on physical interactions, that the gene product of Chrna5
  • is located in the following cellular components:
    • acetylcholine-gated channel complex ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Chrna5
  • participates in the following biological processes:
    • response to nicotine ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Chrna5:
  • participates in the following biological processes:
    • behavioral response to nicotine
  • performs the following molecular functions:
    • acetylcholine binding
    • acetylcholine receptor activity
    • acetylcholine-activated cation-selective channel activity
  • is located in the following cellular components:
    • dendrite
    • neuronal cell body
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Chrna5 encodes a protein or proteins that contain the following InterPro domains: Neurotransmitter-gated ion-channel, Neurotransmitter-gated ion-channel ligand-binding, Neurotransmitter-gated ion-channel transmembrane domain, Neurotransmitter-gated ion-channel, conserved site, Nicotinic acetylcholine receptor, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • extracellular ligand-gated ion channel activity
    • ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • postsynaptic membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chrna5 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane
    • postsynaptic membrane
    • synapse

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References

1. Stitzel JA et al. (1998) Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes. J Pharmacol Exp Ther, 284:1104-11. (PubMed:9495872)
2. Yu WF et al. (2007) Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience, 146:1618-28. (PubMed:17434683)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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