Automated description from the Alliance of Genome Resources (Release 7.0.0)
Contributes to acetylcholine binding activity; acetylcholine receptor activity; and acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in cell surface; neuromuscular junction; and plasma membrane. Part of acetylcholine-gated channel complex. Is active in postsynaptic specialization membrane. Is expressed in several structures, including diaphragm; inner ear; limb bud; skeletal musculature; and tongue. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit).