GO Annotations Graph

• Symbol: Chrna1
• Name: cholinergic receptor nicotinic alpha 1 subunit
• ID: MGI:87885

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042166	acetylcholine binding	IGI	J:36498
Molecular Function	GO:0015464	acetylcholine receptor activity	IDA	J:137435
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	ISO	J:155856
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:19812
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:19812
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	ISO	J:73065
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:19812
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:19812
Molecular Function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:169417
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:164563
Cellular Component	GO:0005892	acetylcholine-gated channel complex	NAS	J:320404
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IPI	J:314963
Cellular Component	GO:0005892	acetylcholine-gated channel complex	ISO	J:155856
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IPI	J:36498
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:169417
Cellular Component	GO:0016020	membrane	IDA	J:157644
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:157644
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:73065
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:102479
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:263579
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:263579
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:79783
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:72247
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:263579
Cellular Component	GO:0099634	postsynaptic specialization membrane	IDA	J:263579
Cellular Component	GO:0045202	synapse	IBA	J:265628
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	IDA	J:317214
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	NAS	J:320302
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0006812	monoatomic cation transport	ISO	J:155856
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0046716	muscle cell cellular homeostasis	ISO	J:164563
Biological Process	GO:0050881	musculoskeletal movement	ISO	J:164563
Biological Process	GO:0050877	nervous system process	IBA	J:265628
Biological Process	GO:0007528	neuromuscular junction development	ISO	J:73065
Biological Process	GO:0050905	neuromuscular process	ISO	J:164563
Biological Process	GO:0007274	neuromuscular synaptic transmission	ISO	J:73065
Biological Process	GO:0070050	neuron cellular homeostasis	ISO	J:164563
Biological Process	GO:0019228	neuronal action potential	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:19812
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:19812
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:73065
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:19812
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:19812
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0003009	skeletal muscle contraction	ISO	J:155856
Biological Process	GO:0003009	skeletal muscle contraction	ISO	J:164563
Biological Process	GO:0048630	skeletal muscle tissue growth	ISO	J:164563