Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pde11a. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pde11a:
  • participates in the following biological processes:
    • cAMP catabolic process
    • cGMP catabolic process
  • performs the following molecular functions:
    • cAMP binding
    • cGMP binding
    • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
    • cyclic-nucleotide phosphodiesterase activity
  • is located in the following cellular components:
    • perikaryon

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Summary text based on GO annotations supported by structural data

• Pde11a encodes a protein or proteins that contain the following InterPro domains: 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, GAF domain, HD/PDEase domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • 3',5'-cyclic-nucleotide phosphodiesterase activity
    • catalytic activity
    • phosphoric diester hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pde11a indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • hydrolase activity
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm
• Pde11a has been associated with the Enzyme Commission numbers: 3.1.4.17, 3.1.4.35, which implies that the gene product:
  • performs the following molecular functions:
    • 3',5'-cyclic-GMP phosphodiesterase activity
    • 3',5'-cyclic-nucleotide phosphodiesterase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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