Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Shroom4. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 13, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to Stocco dos Santos X-linked mental retardation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Shroom4
  • participates in the following biological processes:
    • actin filament organization ^[2]
  • performs the following molecular functions:
    • actin filament binding ^[2]
  • is located in the following cellular components:
    • actin cytoskeleton ^[2]
    • apical plasma membrane ^[2]
    • basal plasma membrane ^[2]
    • cortical actin cytoskeleton ^[1]
    • cytoplasm ^[2]
    • myosin II complex ^[2]
    • stress fiber ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Shroom4:
  • participates in the following biological processes:
    • brain development
    • cognition
  • is located in the following cellular components:
    • cytoplasm
    • internal side of plasma membrane
    • nucleus

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Shroom4 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • performs the following molecular functions:
    • actin binding
  • is located in the following cellular components:
    • cytoskeleton

---

References

1. Dietz ML et al. (2006) Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. J Biol Chem, 281:20542-54. (PubMed:16684770)
2. Yoder M et al. (2007) Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization. Cell Motil Cytoskeleton, 64:49-63. (PubMed:17009331)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---