Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 3.2)

Exhibits sequence-specific DNA binding activity and transcription factor binding activity. Involved in several processes, including cytokine production; positive regulation of macromolecule metabolic process; and response to bacterium. Localizes to NLRP3 inflammasome complex and nucleus. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).

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Gene Ontology Evidence Code Abbreviations:

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