Nlrp3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nlrp3
NLR family, pyrin domain containing 3
MGI:2653833

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	IDA	J:331916
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IDA	J:224866
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding	IDA	J:331916
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding	ISO	J:164563
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	IDA	J:267662
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:192821
Molecular Function	GO:0005515	protein binding	IPI	J:226677
Molecular Function	GO:0005515	protein binding	IPI	J:186690
Molecular Function	GO:0005515	protein binding	IPI	J:186690
Molecular Function	GO:0005515	protein binding	IPI	J:229240
Molecular Function	GO:0005515	protein binding	IPI	J:183942
Molecular Function	GO:0005515	protein binding	IPI	J:279977
Molecular Function	GO:0005515	protein binding	IPI	J:245276
Molecular Function	GO:0005515	protein binding	IPI	J:224866
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:224866
Molecular Function	GO:0043565	sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	IDA	J:331916
Molecular Function	GO:0035591	signaling adaptor activity	IDA	J:233045
Molecular Function	GO:0140299	small molecule sensor activity	IDA	J:331464
Molecular Function	GO:0140299	small molecule sensor activity	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	IDA	J:295244
Cellular Component	GO:0005737	cytoplasm	NAS	J:319953
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:224866
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1250247
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0031021	interphase microtubule organizing center	IDA	J:331916
Cellular Component	GO:0016020	membrane	IDA	J:331916
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:267662
Cellular Component	GO:0016020	membrane	IDA	J:233045
Cellular Component	GO:0005815	microtubule organizing center	ISO	J:164563
Cellular Component	GO:0005815	microtubule organizing center	IDA	J:249560
Cellular Component	GO:0005739	mitochondrion	IDA	J:197368
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0072559	NLRP3 inflammasome complex	ISO	J:164563
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IMP	J:234642
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:224866
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:117613
Biological Process	GO:0002526	acute inflammatory response	IDA	J:295244
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:253629
Biological Process	GO:0071224	cellular response to peptidoglycan	IMP	J:234642
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:234642
Biological Process	GO:0051607	defense response to virus	IMP	J:117613
Biological Process	GO:0009595	detection of biotic stimulus	IDA	J:331464
Biological Process	GO:0009595	detection of biotic stimulus	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IDA	J:253629
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032611	interleukin-1 beta production	IDA	J:295244
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:189777
Biological Process	GO:0032612	interleukin-1 production	IMP	J:117613
Biological Process	GO:0032621	interleukin-18 production	IMP	J:117613
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:295244
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:189777
Biological Process	GO:0002674	negative regulation of acute inflammatory response	ISO	J:164563
Biological Process	GO:0002674	negative regulation of acute inflammatory response	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:197368
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:244223
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:251887
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:249560
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:267662
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:234957
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:331916
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:331917
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:313659
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IDA	J:233045
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IMP	J:189777
Biological Process	GO:0007231	osmosensory signaling pathway	NAS	J:187661
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:320140
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	IMP	J:234642
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:331916
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:257673
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:253629
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:257673
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:234642
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:197368
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:267662
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:205949
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IMP	J:224866
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IDA	J:224866
Biological Process	GO:0032754	positive regulation of interleukin-5 production	IMP	J:224866
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:2000321	positive regulation of T-helper 17 cell differentiation	IMP	J:224866
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	IMP	J:224866
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IMP	J:224866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:224866
Biological Process	GO:0002830	positive regulation of type 2 immune response	IMP	J:224866
Biological Process	GO:0051260	protein homooligomerization	IDA	J:331916
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0051604	protein maturation	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	NAS	J:229325
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:181354

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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