Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc4a7. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc4a7
  • is located in the following cellular components:
    • apical plasma membrane ^[2]
    • basolateral plasma membrane ^[2]
    • cytoplasm ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc4a7
  • participates in the following biological processes:
    • auditory receptor cell development ^[1]
    • camera-type eye photoreceptor cell differentiation ^[1]
    • cochlear nucleus development ^[1]
    • retina vasculature morphogenesis in camera-type eye ^[1]
    • retinal cell programmed cell death ^[1]
    • visual perception ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc4a7:
  • is located in the following cellular components:
    • apical plasma membrane
    • basolateral plasma membrane
    • cytoplasmic vesicle

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Summary text based on GO annotations supported by structural data

• Slc4a7 encodes a protein or proteins that contain the following InterPro domains: Bicarbonate transporter, C-terminal, Bicarbonate transporter, cytoplasmic, Bicarbonate transporter, eukaryotic, Phosphotransferase/anion transporter, Sodium bicarbonate cotransporter, indicating that the gene product:
  • participates in the following biological processes:
    • anion transport
    • transport
  • performs the following molecular functions:
    • anion transmembrane transporter activity
    • inorganic anion exchanger activity
    • transporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc4a7 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • cell projection
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Bok D et al. (2003) Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet, 34:313-9. (PubMed:12808454)
2. Kim YH et al. (2005) Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice. Am J Physiol Renal Physiol, 289:F1262-72. (PubMed:16144965)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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