Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lrp4. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 17, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lrp4
  • participates in the following biological processes:
    • negative regulation of Wnt receptor signaling pathway ^[1]
  • performs the following molecular functions:
    • protein homodimerization activity ^[2]
  • is located in the following cellular components:
    • plasma membrane ^[3]
• The gene product of Lrp4 has been shown to bind to the gene products of Sorl1. ^{[2, 5]} Researchers have inferred, based on physical interactions, that the gene product of Lrp4
  • performs the following molecular functions:
    • receptor tyrosine kinase binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lrp4
  • participates in the following biological processes:
    • anatomical structure development ^[6]
    • dorsal/ventral pattern formation ^{[1, 6]}
    • embryonic digit morphogenesis ^[4]
    • embryonic limb morphogenesis ^{[1, 6]}
    • hair follicle development ^[6]
    • kidney development ^[6]
    • odontogenesis of dentin-containing tooth ^[6]
    • protein localization ^[6]
    • proximal/distal pattern formation ^[6]
    • receptor clustering ^[6]
    • regulation of protein phosphorylation ^[2]
    • synaptic growth at neuromuscular junction ^[6]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lrp4:
  • participates in the following biological processes:
    • negative regulation of canonical Wnt receptor signaling pathway
    • negative regulation of ossification

---

Summary text based on GO annotations supported by structural data

• Lrp4 encodes a protein or proteins that contain the following InterPro domains: EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Growth factor, receptor, LDLR class B repeat, Low-density lipoprotein (LDL) receptor class A repeat, Low-density lipoprotein (LDL) receptor class A, conserved site, Six-bladed beta-propeller, TolB-like, indicating that the gene product:
  • performs the following molecular functions:
    • calcium ion binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lrp4 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • endocytosis
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Johnson EB et al. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet, 14:3523-38. (PubMed:16207730)
2. Kim N et al. (2008) Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell, 135:334-42. (PubMed:18848351)
3. Li Y et al. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J Cell Sci, 118:5305-14. (PubMed:16263759)
4. Simon-Chazottes D et al. (2006) Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse. Genomics, 87:673-7. (PubMed:16517118)
5. Spoelgen R et al. (2009) Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience, 158:1460-8. (PubMed:19047013)
6. Weatherbee SD et al. (2006) LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development, 133:4993-5000. (PubMed:17119023)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---