Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular chloride ion homeostasis; and lymphocyte migration into lymph node. Acts upstream of or within negative regulation of pancreatic juice secretion and positive regulation of systemic arterial blood pressure. Part of protein-containing complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).