GO Annotations Graph

• Symbol: Wnk1
• Name: WNK lysine deficient protein kinase 1
• ID: MGI:2442092

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0019869	chloride channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0019870	potassium channel inhibitor activity	ISO	J:155856
Molecular Function	GO:0019870	potassium channel inhibitor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:197369
Molecular Function	GO:0005515	protein binding	IPI	J:214330
Molecular Function	GO:0005515	protein binding	IPI	J:92516
Molecular Function	GO:0005515	protein binding	IPI	J:92516
Molecular Function	GO:0005515	protein binding	IPI	J:92516
Molecular Function	GO:0005515	protein binding	IPI	J:92516
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:92516
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:259583
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:114792
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:284008
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:1990869	cellular response to chemokine	IMP	J:259583
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	IMP	J:259583
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IGI	J:263369
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0097022	lymphocyte migration into lymph node	IMP	J:259583
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0055080	monoatomic cation homeostasis	IDA	J:84760
Biological Process	GO:0050801	monoatomic ion homeostasis	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IDA	J:84760
Biological Process	GO:0033633	negative regulation of cell-cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0034260	negative regulation of GTPase activity	IMP	J:259583
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0033673	negative regulation of kinase activity	ISO	J:155856
Biological Process	GO:1903038	negative regulation of leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	IMP	J:172037
Biological Process	GO:0010766	negative regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0010766	negative regulation of sodium ion transport	IBA	J:265628
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:259583
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:278187
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:1903288	positive regulation of potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	IMP	J:86696
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ISO	J:164563
Biological Process	GO:0055075	potassium ion homeostasis	IMP	J:284008
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:92516
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:284008
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	ISO	J:164563
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	IMP	J:284008
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:284008
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:259583